251500-M
DAF-2
A highly sensitive and specific fluorescent indicator for the direct detection of nitric oxide (NO) in vitro.
别名:
DAF-2, 4,5-Diaminofluorescein
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关于此项目
经验公式（希尔记法）:
C20H14N2O5
化学文摘社编号:
分子量:
362.34
UNSPSC Code:
12171500
NACRES:
NA.25
MDL number:
产品名称
DAF-2, A highly sensitive and specific fluorescent indicator for the direct detection of nitric oxide (NO) in vitro.
SMILES string
Nc1cc2c(cc1N)C(=O)OC32c4c(cc(cc4)O)Oc5c3ccc(c5)O
InChI
1S/C20H14N2O5/c21-15-7-11-14(8-16(15)22)20(27-19(11)25)12-3-1-9(23)5-17(12)26-18-6-10(24)2-4-13(18)20/h1-8,23-24H,21-22H2
InChI key
LTYUPYUWXRTNFQ-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
solution
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
pale yellow
fluorescence
λex ~495 nm
λem ~515 nm
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
Primary Target
Fluorescent indicator for the direct detection of nitric oxide (NO) in vitro.
Fluorescent indicator for the direct detection of nitric oxide (NO) in vitro.
Disclaimer
Toxicity: Irritant (B)
General description
A highly sensitive and specific fluorescent indicator for the direct detection of nitric oxide (NO) in vivo. The relatively non-fluorescent DAF-2 reacts rapidly with NO in the presence of oxygen to yield the highly fluorescent compound triazolofluorescein (DAF-2 T). Can detect NO under neutral conditions (detection limit = 5 nM). Excitation maximum: 495 nm; emission maximum: 515 nm.
Legal Information
Manufactured by Daiichi Pure Chemicals Co., Ltd
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Berkels, R., et al. 2000. Cell Calcium27, 281.
Kojima, H., et al. 1998. Anal. Chem. 70, 2446.
Kojima, H., et al. 1998. Chem. Pharm. Bull. 46, 373.
Nakatsubo, N., et al. 1998. FEBS Lett. 427, 263.
Kojima, H., et al. 1998. Anal. Chem. 70, 2446.
Kojima, H., et al. 1998. Chem. Pharm. Bull. 46, 373.
Nakatsubo, N., et al. 1998. FEBS Lett. 427, 263.
Physical form
A 5 mM (1 mg in 550 µl) solution in DMSO.
Preparation Note
Following initial thaw, aliquot and freeze (-20°C).
存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
188.6 °F - closed cup - (Dimethylsulfoxide)
flash_point_c
87 °C - closed cup - (Dimethylsulfoxide)
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