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251650

Damnacanthal

Name: Damnacanthal
Brand: MM

A cell-permeable, potent, reversible, and selective inhibitor of p56^lck tyrosine kinase.

别名:

Damnacanthal, 3-Hydroxy-1-methoxyanthraquinone-2-aldehyde

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关于此项目

经验公式（希尔记法）:

C₁₆H₁₀O₅

化学文摘社编号:

477-84-9

分子量:

282.25

MDL number:

MFCD00674209

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥95% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

OK to freeze, protect from light

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属性

Quality Level

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

orange-yellow

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

SMILES string

O(C)c1c2c(cc(c1C=O)O)C(=O)c3c(cccc3)C2=O

InChI

1S/C16H10O5/c1-21-16-11(7-17)12(18)6-10-13(16)15(20)9-5-3-2-4-8(9)14(10)19/h2-7,18H,1H3

InChI key

IPDMWUNUULAXLU-UHFFFAOYSA-N

说明

General description

A cell-permeable, potent, reversible, and selective inhibitor of p56^lck tyrosine kinase. Inhibits p56^lck autophosphorylation (IC₅₀ = 17 nM) and phosphorylation of an exogenous peptide by p56^lck (IC₅₀ = 620 nM). Exhibits over 100-fold greater selectivity for p56^lck over PKA and PKC, 40-fold greater selectivity for p56^lck over EGF receptor kinase, c-ErbB2, insulin receptor kinase, and PDGF receptor kinase, and 7 - 20-fold greater selectivity for p56^lck over p60^srcand p59^fyn. Inhibition of p56^lck is not significantly affected by the presence of sulfhydryl reagents. Also known to have antimalarial properties and to reverse the phenotype of ras-transformed cells.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
p56^lck autophosphorylation

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 17 nM against p56lck autophosphorylation

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Other Notes

Faltynek, C.R., et al. 1995. Biochemistry34, 12404.
Hiramatsu, T., et al. 1993. Cancer Lett.73, 161.
Koumaglo, K., et al. 1992. Planta Med.58, 533.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

存储类别

11 - Combustible Solids

wgk

WGK 1

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全球贸易项目编号

货号	GTIN
251650-1MG	04055977198553