251800
Daunorubicin, Hydrochloride
Potent cell-permeable anticancer agent whose potential target site may be mitochondrial cytochrome c oxidase.
别名:
Daunorubicin, Hydrochloride, Daunomycin, HCl
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关于此项目
经验公式（希尔记法）:
C27H29NO10 · xHCl
化学文摘社编号:
分子量:
527.52 (free base basis)
NACRES:
NA.77
UNSPSC Code:
12352200
MDL number:
Form:
crystalline solid
Quality level:
Storage condition:
OK to freeze, desiccated (hygroscopic)
InChI
1S/C27H29NO10.ClH/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33;/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3;1H/t10-,14-,16-,17-,22+,27-;/m0./s1
InChI key
GUGHGUXZJWAIAS-QQYBVWGSSA-N
form
crystalline solid
potency
≥840 g/kg
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic)
color
red
solubility
aqueous buffer: soluble, methanol: soluble, water: soluble
shipped in
ambient
storage temp.
10-30°C
Quality Level
General description
Potent cell-permeable anticancer agent whose potential target site may be mitochondrial cytochrome C oxidase. Has been shown to inhibit RNA and DNA synthesis and to intercalate into DNA. Inhibits eukaryotic topoisomerase I and II. Induces DNA single strand breaks. Induces apoptosis in HeLaS3 tumor cells.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
DNA synthesis, RNA synthesis
DNA synthesis, RNA synthesis
Product does not compete with ATP.
Reversible: no
Preparation Note
Following reconstitution, store in the refrigerator (4°C). Aqueous stock solutions are stable for up to 1 month at 4°C.
Other Notes
Friedenberg, W.R., et al. 1995. Am. J. Clin. Oncol. 18, 105.
Papadopoulou, L.C., and Tsiftsoglou, A.S. 1993. Cancer Res. 53, 1072.
Skladanowski, A., and Konopa, J. 1993. Biochem. Pharmacol.46, 375.
Wolff, M., and Jelkmann, W. 1993. Ann. Hematol. 66, 27.
Bellec, F., et al. 1992. Flow Cytometry 13, 880.
Papadopoulou, L.C., and Tsiftsoglou, A.S. 1993. Cancer Res. 53, 1072.
Skladanowski, A., and Konopa, J. 1993. Biochem. Pharmacol.46, 375.
Wolff, M., and Jelkmann, W. 1993. Ann. Hematol. 66, 27.
Bellec, F., et al. 1992. Flow Cytometry 13, 880.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Harmful & Carcinogenic / Teratogenic (E)
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Carc. 2 - Muta. 2 - Repr. 1B
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
Pietri Puustinen et al.
Autophagy, 16(10), 1871-1888 (2020-01-28)
Macroautophagy/autophagy is a central component of the cytoprotective cellular stress response. To enlighten stress-induced autophagy signaling, we screened a human kinome siRNA library for regulators of autophagic flux in MCF7 human breast carcinoma cells and identified the catalytic subunit of
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