260913
DNase I，来源于牛胰腺
Native DNase I from bovine pancreas.
别名:
DNase I，来源于牛胰腺, 脱氧核糖核酸酶 I（DNA酶I）
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关于此项目
化学文摘社编号:
UNSPSC Code:
12352202
NACRES:
NA.54
MDL number:
Specific activity:
≥60,000 dornase units/mg dry wt
Biological source:
bovine pancreas
biological source
bovine pancreas
description
Merck USA index - 14, 2906
form
lyophilized
specific activity
≥60,000 dornase units/mg dry wt
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated
solubility
sodium acetate buffer: soluble, water: soluble
shipped in
ambient
storage temp.
−20°C
General description
来自牛胰脏的天然DNase I。一种优先裂解与嘧啶核苷酸相邻的磷酸二酯键以产生在3′位具有游离羟基的5′-磷酸末端多核苷酸的核酸内切酶。作用于单链和双链DNA。注意：1 MU = 1,000,000 Dornase单位
注意：32个Dornase单位等于~1 Kunitz单位；1 MU=1,000,000 Dornase单位。
Preparation Note
复溶后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多3个月。
Other Notes
Takeshita, H., et al. 2000.Biochem.Biophys.Res. Commun.269, 481.
Jones, S.J., et al. 1996.J. Mol.Biol.264, 1154.
Jones, S.J., et al. 1996.J. Mol.Biol.264, 1154.
一个Dornase单位定义为在30°C下10分钟内将导致高度聚合的DNA溶液中相对粘度单位从初始相对粘度4.0降低1.0的酶量。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
signalword
Danger
hcodes
pcodes
Hazard Classifications
Resp. Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Bin Du et al.
Cancer letters, 470, 170-180 (2019-11-26)
Cyclophosphamide treatment on a medium-dose, intermittent chemotherapy (MEDIC) schedule activates both innate and adaptive immunity leading to major regression of implanted gliomas. Here, we show that this MEDIC treatment regimen induces tumor cell autonomous type-I interferon signaling, followed by release
Derek Toms et al.
Frontiers in bioengineering and biotechnology, 8, 534-534 (2020-06-26)
We have developed an accessible software tool (receptoR) to predict potentially active signaling pathways in one or more cell type(s) of interest from publicly available transcriptome data. As proof-of-concept, we applied it to mouse photoreceptors, yielding the previously untested hypothesis
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