260920
DNA Methyltransferase Inhibitor
The DNA Methyltransferase Inhibitor, also referenced under CAS 32675-71-1, controls the biological activity of DNA Methyltransferase. This small molecule/inhibitor is primarily used for Cell Structure applications.
别名:
DNA Methyltransferase Inhibitor, 2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propionic acid, RG108, DNA MTase Inhibitor I
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关于此项目
经验公式（希尔记法）:
C19H14N2O4
化学文摘社编号:
分子量:
334.33
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.54
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥98% (HPLC)
form
solid
potency
115 nM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow
solubility
DMSO: 100 mg/mL, methanol: soluble
shipped in
ambient
storage temp.
2-8°C
SMILES string
[nH]1c2c(c(c1)CC(N3C(=O)c4c(cccc4)C3=O)C(=O)O)cccc2
InChI
1S/C19H14N2O4/c22-17-13-6-1-2-7-14(13)18(23)21(17)16(19(24)25)9-11-10-20-15-8-4-3-5-12(11)15/h1-8,10,16,20H,9H2,(H,24,25)
InChI key
HPTXLHAHLXOAKV-UHFFFAOYSA-N
General description
A cell-permeable, specific DNA methyltransferases inhibitor (IC50 = 115 nM for CpG methylase M.SssI) that displays anti-proliferative, but not cytotoxic, properties. Unlike the commonly used inhibitor 5-azacytidine, RG108 directly interacts with DNA methyltransferase active site via its carboxy group.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
CPG methylase M.Sssl
CPG methylase M.Sssl
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Brueckner, B., et al. 2005. Cancer Res.65, 6305.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable