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260960

DNA-PK Inhibitor

Name: DNA-PK Inhibitor
Brand: MM

The DNA-PK Inhibitor, also referenced under CAS 20357-25-9, controls the biological activity of DNA-PK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

别名:

DNA-PK Inhibitor, DMNB, 4,5- Di methoxy-2- nitro benzaldehyde, DNA-Dependent Protein Kinase Inhibitor, DMNB, 4,5-Dimethoxy-2-nitrobenzaldehyde, DNA-Dependent Protein Kinase Inhibitor

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关于此项目

经验公式（希尔记法）:

C₉H₉NO₅

化学文摘社编号:

20357-25-9

分子量:

211.17

UNSPSC Code:

12352100

NACRES:

NA.77

MDL number:

MFCD00007134

Assay:

≥90% (GC)

Form:

solid

Quality level:

100

Storage condition:

OK to freeze, protect from light

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属性

Quality Level

100

assay

≥90% (GC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

bright yellow

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

[N+](=O)([O-])c1c(cc(c(c1)OC)OC)C=O

InChI

1S/C9H9NO5/c1-14-8-3-6(5-11)7(10(12)13)4-9(8)15-2/h3-5H,1-2H3

InChI key

YWSPWKXREVSQCA-UHFFFAOYSA-N

说明

General description

A cell-permeable vanillin derivative that acts as a potent and selective inhibitor of DNA-PK (DNA-dependent protein kinase) activity (IC₅₀ = 15 µM) and DNA-PK-mediated DSB (double strand break) DNA repair by NHEJ (non-homologous DNA-end-joining). Shown to effectively sensitize cells to killing by Cisplatin (Cat. No. 232120 ). Does not affect PKC or Chk2 kinase activities.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
DNA-PK activity

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 15 µM against DNA-PK (DNA-dependent protein kinase) activity

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Willmore, E., et al. 2004. Blood,103, 4659.
Durant, S., and Karran, P. 2003. Nucleic Acids Res.31, 5501.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Carcinogenic / Teratogenic (D)

存储类别

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c