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Merck
CN

264103

脱氧胆酸钠

ULTROL® Grade, ≥99% (TLC), detergent to solubilize membrane-bound proteins in their native state

别名:

3α,12α-二羟-5β-胆烷酸 钠盐, 去氧胆酸 钠盐, 脱氧胆酸 钠盐

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关于此项目

经验公式（希尔记法）:
C24H39NaO4
化学文摘社编号:
302-95-4
分子量:
414.55
NACRES:
NA.21
UNSPSC Code:
12161902
Beilstein/REAXYS Number:
3581950
MDL number:
MFCD00064139

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产品名称

脱氧胆酸钠, ULTROL® Grade, ≥99% (TLC), detergent to solubilize membrane-bound proteins in their native state

SMILES string

[Na+].[H][C@]12CC[C@@]3([H])[C@]4([H])CC[C@H]([C@H](C)CCC([O-])=O)[C@@]4(C)[C@@H](O)C[C@]3([H])[C@@]1(C)CC[C@@H](O)C2

InChI key

FHHPUSMSKHSNKW-SMOYURAASA-M

InChI

1S/C24H40O4.Na/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3;/h14-21,25-26H,4-13H2,1-3H3,(H,27,28);/q;+1/p-1/t14-,15-,16-,17+,18-,19+,20+,21+,23+,24-;/m1./s1

description

Merck USA index - 14, 2899

assay

≥99% (TLC)

form

solid

mol wt

micellar avg mol wt 1200-5000
micellar wt 1200-4900

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

aggregation number

3 - 12
 3-12

color

white

pKa 

6.2

CMC

2 - 6 mM
2-6 mM (20-25°C)

HLB

16

shipped in

ambient

storage temp.

15-25°C

Quality Level

100

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相关类别

Application


  • Treatment of mucocutaneous leishmaniasis - A systematic review.: Sodium deoxycholate is discussed in this systematic review as a component in treatment regimens for mucocutaneous leishmaniasis, offering comprehensive insights into current therapeutic approaches and outcomes (Fischer et al., 2024).

Disclaimer

Toxicity: Harmful (C)

General description

Absorbance (10%, H2O, 290 nm):≤0.25.
Highly purified and intended for use as a detergent to solubilize membrane-bound proteins in their native state (absorbance: <0.25 at 290 nm, 10% H2O; aggregation number: 3-12; CMC: 2-6 mM; micellar weight: 1200-4900; pKa: 6.2). Reported to induce tyrosine phosphorylation of β-catenin and its subsequent translocation to the nucleus, promoting activation of β-catenin signaling (effective concentration 5-50 µM).

Other Notes

Pai, R., et al. Mol. Biol. Cell15, 2156.

Preparation Note

Do not use with Mn2+ in solution.
Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 6 months at 4°C. Discard if bacterial or fungal growth is observed.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
ULTROL is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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