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Merck
CN

264155

Sigma-Aldrich

半胱氨酸蛋白酶-3抑制物II

≥90% (TLC), irreversible CPP-32/apopain inhibitor, solid

别名:

半胱氨酸蛋白酶-3抑制物II, Z-D（OMe）E（OMe）VD（OMe）-FMK

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关于此项目

经验公式（希尔记法）:
C30H41FN4O12
CAS Number:
210344-95-9
分子量:
668.66
MDL编号:
MFCD23380217
UNSPSC代码:
12352200
NACRES:
NA.77

主要文件

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Product Name

半胱氨酸蛋白酶-3抑制物II, The Caspase-3 Inhibitor II, also referenced under CAS 210344-95-9, controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications.

质量水平

200

方案

≥90% (TLC)

表单

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
desiccated

颜色

white to slightly brown

溶解性

DMSO: 5 mg/mL

运输

ambient

储存温度

−20°C

SMILES字符串

FCC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)OCc1ccccc1)CC(=O)OC)CCC(=O)OC)C(C)C)CC(=O)OC

InChI

1S/C30H41FN4O12/c1-17(2)26(29(42)33-20(22(36)15-31)13-24(38)45-4)35-27(40)19(11-12-23(37)44-3)32-28(41)21(14-25(39)46-5)34-30(43)47-16-18-9-7-6-8-10-18/h6-10,17,19-21,26H,11-16H2,1-5H3,(H,32,41)(H,33,42)(H,34,43)(H,35,40)/t19-,20-,21-,26-/m0/s1

InChI key

GBJVAVGBSGRRKN-JYEBCORGSA-N

相关类别

一般描述

CPP-32/Apopain（半胱氨酸蛋白酶的ICE/CED-3家族成员）的有效，细胞可渗透且不可逆的抑制剂。
半胱天冬酶-3以及半胱天冬酶-6、半胱天冬酶-7、半胱天冬酶-8和半胱天冬酶-10的有效，细胞可渗透且不可逆的抑制剂。当与纯化的天然或重组酶一起使用时，需要用酯酶进行预处理。

生化/生理作用

主要靶标
半胱天冬酶-3，半胱天冬酶-6，半胱天冬酶-7，半胱天冬酶-8，半胱天冬酶-10
产物不与ATP竞争。
可逆：否
细胞可渗透性：是

制备说明

复溶后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多3个月。

其他说明

Thornberry, N.A., and Lazebnik, Y. 1998.Science 281, 1312.
Masuda, Y., et al. 1997.Biochem.Biophys.Res. Commun.234, 641.
Nicholson, D.W.1996.Nature Biotech.14, 297.
Schlegel, J., et al. 1996.J. Biol. Chem. 271, 1841.
Nicholson, D.W., et al. 1995.Nature 376, 37.
Z-Asp(OCH₃)-Glu(OCH₃)-Val-Asp(OCH₃)-FMK

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

毒性：标准处理（A）

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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Susanna Narkilahti et al.
The European journal of neuroscience, 18(6), 1486-1496 (2003-09-27)
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