286888
BHQ
Mobilizes Ca2+ specifically from Ins(1,4,5)P3-sensitive Ca2+ stores by inhibiting microsomal and sarcoplasmic reticulum Ca2+-ATPase activity.
别名:
BHQ, 2,5-Di-( t-butyl)-1,4-hydroquinone, t-BuBHQ, 2,5-Di-(t-butyl)-1,4-hydroquinone, t-BuBHQ
InChI
1S/C14H22O2/c1-13(2,3)9-7-12(16)10(8-11(9)15)14(4,5)6/h7-8,15-16H,1-6H3
InChI key
JZODKRWQWUWGCD-UHFFFAOYSA-N
assay
≥99% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
DMSO: 1 mM, ethanol: 25 mg/mL, methanol: soluble
shipped in
ambient
storage temp.
10-30°C
Quality Level
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Biochem/physiol Actions
Cell permeable: no
Primary Target
micosomal and sarcoplasmic reticulation Ca2+ ATPase activity
micosomal and sarcoplasmic reticulation Ca2+ ATPase activity
Product does not compete with ATP.
Reversible: no
Disclaimer
Toxicity: Standard Handling (A)
General description
Mobilizes Ca2+ specifically from the Ins(1,4,5)P3-sensitive Ca2+ stores by inhibiting microsomal and sarcoplasmic reticulum Ca2+-ATPase activity. Does not affect mitochondrial Ca2+ fluxes or plasma membrane Ca2+/Mg2+ ATPase activity. Useful for the study of endomembrane Ca2+ stores and plasma membrane Ca2+ permeability pathways.
Other Notes
Salvador, J.M., and Mata, A.M. 1998. Arch. Biochem. Biophys. 351, 272.
Leis, H.J., et al. 1996. Br. J. Pharmacol. 117, 540.
Khan, Y.M., et al. 1995. Biochemistry 34, 14385.
Hassessian, H., et al. 1994. Br. J. Pharmacol. 112, 1118.
Khodorova, A.B., and Astashkin, E.I. 1994. FEBS Lett. 353, 167.
Schilling, W.P., et al. 1992. Biochem. J.284, 521.
Wictome, M., et al. 1992. FEBS Lett.304, 109.
Mason, M.J., et al. 1991. J. Biol. Chem.266, 20856.
Kass, G.N., et al. 1989. J. Biol. Chem.264, 15192.
Leis, H.J., et al. 1996. Br. J. Pharmacol. 117, 540.
Khan, Y.M., et al. 1995. Biochemistry 34, 14385.
Hassessian, H., et al. 1994. Br. J. Pharmacol. 112, 1118.
Khodorova, A.B., and Astashkin, E.I. 1994. FEBS Lett. 353, 167.
Schilling, W.P., et al. 1992. Biochem. J.284, 521.
Wictome, M., et al. 1992. FEBS Lett.304, 109.
Mason, M.J., et al. 1991. J. Biol. Chem.266, 20856.
Kass, G.N., et al. 1989. J. Biol. Chem.264, 15192.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Skin Sens. 1 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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