287810
2′,7′-二氯荧光素二醋酸盐
Cell-permeable fluorogenic probe that is useful for the detection of reactive oxygen species (ROS) and nitric oxide (•NO) and for the determination of the degree of overall oxidative stress.
别名:
2′,7′-二氯荧光素二醋酸盐, H₂DCFDA, 2ʹ,7ʹ-二氯二氢荧光素二乙酸酯
质量水平
方案
≥94% (HPLC)
表单
crystalline solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
溶解性
DMSO: 5 mg/mL
运输
ambient
储存温度
−20°C
SMILES字符串
Clc1cc2c(cc1OC(=O)C)Oc3c(cc(c(c3)OC(=O)C)Cl)C2c4c(cccc4)C(=O)O
InChI
1S/C24H16Cl2O7/c1-11(27)31-21-9-19-15(7-17(21)25)23(13-5-3-4-6-14(13)24(29)30)16-8-18(26)22(32-12(2)28)10-20(16)33-19/h3-10,23H,1-2H3,(H,29,30)
InChI key
PXEZTIWVRVSYOK-UHFFFAOYSA-N
一般描述
细胞可透过性荧光探针，可用于检测中性粒细胞和巨噬细胞中的活性氧（ROS）和一氧化氮（NO），测定毒理学现象中的整体氧化应激程度。
生化/生理作用
主要目的
检测活性氧（ROS）和一氧化氮（•NO）
检测活性氧（ROS）和一氧化氮（•NO）
产品不与ATP竞争。
可逆：否
细胞渗透性：是
包装
用惰性气体包装
制备说明
溶解后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多3个月。
其他说明
Crow, J.P. 1997.Nitric Oxide 1, 145.
Ripple, M.O., et al. 1997.J. Natl.Cancer Inst.89, 40.
Caro, A., and Puntarulo, S. 1996.Biochim.Biophys.Acta1291, 245.
Perez-Garcia, F., et al. 1996.Life Sci. 59, 2033.
Ramakrishnan, N., et al. 1996.生物化学。Pharmacol.51, 1443.
Ferrer, A.S., et al. 1990.Anal.生物化学。187, 129.
Ripple, M.O., et al. 1997.J. Natl.Cancer Inst.89, 40.
Caro, A., and Puntarulo, S. 1996.Biochim.Biophys.Acta1291, 245.
Perez-Garcia, F., et al. 1996.Life Sci. 59, 2033.
Ramakrishnan, N., et al. 1996.生物化学。Pharmacol.51, 1443.
Ferrer, A.S., et al. 1990.Anal.生物化学。187, 129.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
毒性：标准处理（A）
储存分类代码
11 - Combustible Solids
WGK
WGK 3
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