287810
2′,7′-二氯荧光素二醋酸盐
Cell-permeable fluorogenic probe that is useful for the detection of reactive oxygen species (ROS) and nitric oxide (•NO) and for the determination of the degree of overall oxidative stress.
别名:
2′,7′-二氯荧光素二醋酸盐, H₂DCFDA, 2ʹ,7ʹ-二氯二氢荧光素二乙酸酯
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关于此项目
经验公式（希尔记法）:
C24H16Cl2O7
化学文摘社编号:
分子量:
487.29
UNSPSC Code:
12352202
NACRES:
NA.25
MDL number:
产品名称
2′,7′-二氯荧光素二醋酸盐, Cell-permeable fluorogenic probe that is useful for the detection of reactive oxygen species (ROS) and nitric oxide (•NO) and for the determination of the degree of overall oxidative stress.
SMILES string
Clc1cc2c(cc1OC(=O)C)Oc3c(cc(c(c3)OC(=O)C)Cl)C2c4c(cccc4)C(=O)O
InChI
1S/C24H16Cl2O7/c1-11(27)31-21-9-19-15(7-17(21)25)23(13-5-3-4-6-14(13)24(29)30)16-8-18(26)22(32-12(2)28)10-20(16)33-19/h3-10,23H,1-2H3,(H,29,30)
InChI key
PXEZTIWVRVSYOK-UHFFFAOYSA-N
assay
≥94% (HPLC)
form
crystalline solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
solubility
DMSO: 5 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
主要目的
检测活性氧（ROS）和一氧化氮（•NO）
检测活性氧（ROS）和一氧化氮（•NO）
产品不与ATP竞争。
可逆：否
细胞渗透性：是
Disclaimer
毒性：标准处理（A）
General description
细胞可透过性荧光探针，可用于检测中性粒细胞和巨噬细胞中的活性氧（ROS）和一氧化氮（NO），测定毒理学现象中的整体氧化应激程度。
Other Notes
Crow, J.P. 1997.Nitric Oxide 1, 145.
Ripple, M.O., et al. 1997.J. Natl.Cancer Inst.89, 40.
Caro, A., and Puntarulo, S. 1996.Biochim.Biophys.Acta1291, 245.
Perez-Garcia, F., et al. 1996.Life Sci. 59, 2033.
Ramakrishnan, N., et al. 1996.生物化学。Pharmacol.51, 1443.
Ferrer, A.S., et al. 1990.Anal.生物化学。187, 129.
Ripple, M.O., et al. 1997.J. Natl.Cancer Inst.89, 40.
Caro, A., and Puntarulo, S. 1996.Biochim.Biophys.Acta1291, 245.
Perez-Garcia, F., et al. 1996.Life Sci. 59, 2033.
Ramakrishnan, N., et al. 1996.生物化学。Pharmacol.51, 1443.
Ferrer, A.S., et al. 1990.Anal.生物化学。187, 129.
Packaging
用惰性气体包装
Preparation Note
溶解后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多3个月。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 3
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