跳转至内容
Merck
CN

287840

Diclofenac sodium salt

≥98% (TLC), Cyclooxygenase COX-1 and COX-2 inhibitor, solid

别名:

Diclofenac Sodium, 2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid, Na

登录 查看组织和合同定价。

选择尺寸

关于此项目

经验公式（希尔记法）:
C14H10Cl2NO2 · Na
化学文摘社编号:
15307-79-6
分子量:
318.13
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00082251
Assay:
≥98% (TLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze
desiccated (hygroscopic)

主要文件

查看所有文档
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助

产品名称

Diclofenac Sodium, A cell-permeable, non-selective cyclooxygenase inhibitor (IC50 = 60 nM and 200 nM for ovine COX-1 and COX-2 respectively) and potent non-steroidal anti-inflammatory drug with analgesic activity.

SMILES string

[Na+].Clc1c(c(ccc1)Cl)Nc2c(cccc2)CC(=O)[O-]

InChI

1S/C14H11Cl2NO2.Na/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;/h1-7,17H,8H2,(H,18,19);/q;+1/p-1

InChI key

KPHWPUGNDIVLNH-UHFFFAOYSA-M

description

Merck USA index - 14, 3081

assay

≥98% (TLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

color

white

solubility

water: 25 mg/mL

shipped in

ambient

storage temp.

10-30°C

Quality Level

100

相关类别

Biochem/physiol Actions

Cell permeable: yes
Primary Target
COX-1
Product does not compete with ATP.
Reversible: no
Target IC50: 60 nM and 200 nM for ovine COX-1 and COX-2 respectively; 9.5 µM against liver phenol sulfotransferase activity

Disclaimer

Toxicity: Toxic & Carcinogenic / Teratogenic (G)

General description

A cell-permeable, non-selective cyclooxygenase inhibitor (IC50 = 60 nM and 200 nM for ovine COX-1 and COX-2 respectively) and potent non-steroidal anti-inflammatory drug with analgesic activity. Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation. Also inhibits liver phenol sulfotransferase activity (IC50 = 9.5 µM).
A potent non-steroidal anti-inflammatory drug that inhibits both COX-1 (IC50 = 76 nM) and COX-2 (IC50 = 26 nM) activities. Also inhibits liver phenol sulfotransferase activity (IC50 ~9.5 µM). Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Kato, M., et al. 2001. J. Pharm. Pharmacol.53, 1679.
Klabunde, T., et al. 2000. Nat. Struct. Biol.7, 312.
Vietri, M., et al. 2000. Eur J. Clin. Pharmacol. 56, 81.
Merlos, M., et al. 1996. Inflamm. Res.45, 20.
Goa, K.L., and Chrisp, P. 1992. Drugs Aging 2, 473.
Kurowski, M., and Dunky, A. 1992. Int. J. Clin. Pharmacol. Ther. Toxicol. 30, 479.

Preparation Note

Following reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Chronic 2 - Repr. 2 - STOT RE 1

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持