288500-M
DL-α二氟甲基鸟氨酸盐酸盐
A cell-permeable, anticancer agent that acts as a specific and irreversible inhibitor of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis.
别名:
DL-α二氟甲基鸟氨酸盐酸盐, DFMO，依氟鸟氨酸，RMI-71782
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关于此项目
经验公式（希尔记法）:
C6H12F2N2O2 · xHCl · yH2O
化学文摘社编号:
分子量:
182.17 (anhydrous free base basis)
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥99% (HPLC)
Form:
powder
Storage condition:
OK to freeze, desiccated (hygroscopic)
Quality Segment
description
Merck USA index - 14, 3522
assay
≥99% (HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic)
color
white
solubility
water: 1 mg/mL, methanol: 25 mg/mL
storage temp.
10-30°C
SMILES string
FC(F)C(N)(CCCN)C(=O)O.[Cl-].O.[H+]
InChI
1S/C6H12F2N2O2.ClH.H2O/c7-4(8)6(10,5(11)12)2-1-3-9;;/h4H,1-3,9-10H2,(H,11,12);1H;1H2
InChI key
FJPAMFNRCFEGSD-UHFFFAOYSA-N
General description
一种细胞可渗透的抗癌剂，可作为鸟氨酸脱羧酶（ODC）的特异性和不可逆抑制剂，鸟氨酸脱羧酶是多胺生物合成中的限速酶。抑制B16黑色素瘤诱导的卵内血管生成和体外血管内皮细胞增殖。
Biochem/physiol Actions
主要靶标
ODC
ODC
Preparation Note
复溶后，等分并冷冻（-20°C）。储备溶液在-20°C下可稳定保存至多3个月。
Other Notes
Meyskens, F.L., Jr., and Gerner, E.W.1995.J. Cell.Biochem.(Suppl.) 22, 126.
Feuerstein, B.G., et al. 1992.Cancer Res. 52, 6782.
Takigawa, M., et al. 1990.Cancer Res.50, 4131.
Weeks, C.E., et al. 1982.Proc.Natl.Acad.Sci. USA 79, 6028.
Danzin, C., et al. 1979.Life Sci. 24, 519.
Feuerstein, B.G., et al. 1992.Cancer Res. 52, 6782.
Takigawa, M., et al. 1990.Cancer Res.50, 4131.
Weeks, C.E., et al. 1982.Proc.Natl.Acad.Sci. USA 79, 6028.
Danzin, C., et al. 1979.Life Sci. 24, 519.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：致癌/致畸（D）
存储类别
11 - Combustible Solids
怎么回事？
WGK 3
闪点 (F)
Not applicable
闪点 (°C)
Not applicable