298711
Diethyl Pyrocarbonate
≥97% (titration), ryanodine inhibitor, liquid
别名:
Diethyl Pyrocarbonate, Diethyl Oxydiformate, DEPC
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关于此项目
经验公式（希尔记法）:
C6H10O5
化学文摘社编号:
分子量:
162.14
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
Diethyl Pyrocarbonate, Inhibits ryanodine binding to ryanodine/Ca2+ receptor channel in skeletal muscle in a dose- and time-dependent manner and increases the Ca2+ permeability of SR vesicles.
SMILES string
O(CC)C(=O)OC(=O)OCC
InChI
1S/C6H10O5/c1-3-9-5(7)11-6(8)10-4-2/h3-4H2,1-2H3
InChI key
FFYPMLJYZAEMQB-UHFFFAOYSA-N
description
Merck USA index - 14, 7998
assay
≥97% (titration)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
clear colorless
solubility
chloroform: soluble, ethanol: soluble
shipped in
ambient
Quality Level
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General description
Inhibits ryanodine binding to ryanodine/Ca2+ receptor channel in skeletal muscle in a dose- and time-dependent manner and increases the Ca2+ permeability of SR vesicles. Useful for specific inactivation of nucleases during isolation of undegraded polynucleotides. Also inhibits platelet-activating factor acetyl hydrolase. Has been used as a probe for the topography of 5.8S rRNA in yeast ribosomes.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Inhibits ryanodine binding to ryanodine/Ca2+ receptor channel in skeletal muscle
Inhibits ryanodine binding to ryanodine/Ca2+ receptor channel in skeletal muscle
Product does not compete with ATP.
Reversible: no
Other Notes
Shoshan-Barmatz, V., and Weil, S. 1994. Biochem. J. 299, 177.
Blumbers, D.O. 1987. Methods Enzymol. 152, 20.
Blumbers, D.O. 1987. Methods Enzymol. 152, 20.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Harmful (C)
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
156.2 °F - closed cup
flash_point_c
69 °C - closed cup
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