309795
DIDS disodium salt
≥85% (HPLC), solid, anion transport inhibitor, Calbiochem®
别名:
DIDS，二钠盐, 4,4ʹ-二异硫氰基芪-2,2ʹ-二磺酸, 2Na
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关于此项目
经验公式（希尔记法）:
C16H8N2O6S4 · 2Na
化学文摘社编号:
分子量:
498.48
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥85% (HPLC)
Form:
solid
Storage condition:
OK to freeze, desiccated, protect from light
产品名称
DIDS，二钠盐, Binds covalently and irreversibly to the outer surface of human erythrocyte membranes.
Quality Segment
assay
≥85% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated, protect from light
color
yellow
solubility
water: 0.5%
shipped in
ambient
storage temp.
−20°C
SMILES string
[S](=O)(=O)(O)c1c(ccc(c1)N=C=S)\C=C\c2c(cc(cc2)N=C=S)[S](=O)(=O)O
InChI
1S/C16H10N2O6S4/c19-27(20,21)15-7-13(17-9-25)5-3-11(15)1-2-12-4-6-14(18-10-26)8-16(12)28(22,23)24/h1-8H,(H,19,20,21)(H,22,23,24)/b2-1+
InChI key
YSCNMFDFYJUPEF-OWOJBTEDSA-N
General description
与人红细胞膜蛋白的外表面不可逆地共价结合。抑制 ATP向内质网囊泡的转运抑制神经母细胞瘤细胞中 Cl - 摄入（IC50= 150 nM）的阴离子转运抑制剂。具有抗溃疡活性。
Biochem/physiol Actions
主要靶标
Cl-摄入
Cl-摄入
产物不与ATP竞争。
可逆：否
细胞渗透性：否
靶标IC50：150 nM抑制神经母细胞瘤细胞中的Cl- 摄入
Other Notes
Bettendorff, L., et al. 1995.Biochem.Biophys.Res. Commun.207, 375.
Horie, S., et al. 1993.Res. Commun.Chem. Pathol.Pharmacol.79, 117.
Mayinger, P., and Meyer, D.I.1993.EMBO J. 12, 659.
Catantchik, Z.I., and Rothstein, A. 1974.J. Membr.Biol.15, 207.
Horie, S., et al. 1993.Res. Commun.Chem. Pathol.Pharmacol.79, 117.
Mayinger, P., and Meyer, D.I.1993.EMBO J. 12, 659.
Catantchik, Z.I., and Rothstein, A. 1974.J. Membr.Biol.15, 207.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：刺激性（B）
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 309795-250MG | 04055977216790 |