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Merck
CN

317642

Sigma-Aldrich

K579

≥97% (HPLC), DPP IV inhibitor, solid

别名:

Dipeptidylpeptidase IV Inhibitor IV, K579, (S)-1-(4-Methyl-1-(2-pyrimidinyl)-4-piperidylamino)acetyl-2-pyrrolidinecarbonitrile, DPP IV Inhibitor IV

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About This Item

经验公式（希尔记法）:
C17H24N6O
CAS Number:
440100-64-1
分子量:
328.41
MDL编号:
MFCD07364044
UNSPSC代码:
12352200
NACRES:
NA.77

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Product Name

Dipeptidylpeptidase IV Inhibitor IV, K579, The Dipeptidylpeptidase IV Inhibitor IV, K579, also referenced under CAS 440100-64-1, controls the biological activity of Dipeptidylpeptidase IV. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

质量水平

100

方案

≥97% (HPLC)

表单

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
protect from light

颜色

off-white to light brown

溶解性

1 M HCl: 16 mg/mL
DMSO: 32 mg/mL
ethanol: 6.5 mg/mL

运输

ambient

储存温度

2-8°C

SMILES字符串

N3([C@@H](CCC3)C#N)C(=O)CNC1(CCN(CC1)c2ncccn2)C

InChI

1S/C17H24N6O/c1-17(21-13-15(24)23-9-2-4-14(23)12-18)5-10-22(11-6-17)16-19-7-3-8-20-16/h3,7-8,14,21H,2,4-6,9-11,13H2,1H3/t14-/m0/s1

InChI key

JERPHRNGJBSFAP-AWEZNQCLSA-N

相关类别

一般描述

A cyanopyrrolidine compound that acts as a potent DPP IV inhibitor (IC50 = 3, 5, 8, and 8 nM in inhibiting rat, human, monkey, and canine DDP IV, respectively). Oral administration of K579 in rats in vivo has been shown to reduce blood DPP IV activity and augment GLP-1 and insulin response after glucose intake and significantly reduce plasma glucose concentration.
Please note: 328.4 is the anhydrous molecular weight; please refer to the vial label for the lot-specific hydration and molecular weight.

包装

Packaged under inert gas

其他说明

Please note: 328.4 is the anhydrous molecular weight; please refer to the vial label for the lot-specific hydration and molecular weight.
Takasaki, K., et al. 2004. Eur. J. Pharmacol.505, 237.
Takasaki, K., et al. 2004. Eur. J. Pharmacol.486, 335.
Takasaki, K., et al. 2004. J. Pharmacol. Sci.95, 291.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Toxicity: Standard Handling (A)

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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