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Merck
CN

317642

K579

≥97% (HPLC), DPP IV inhibitor, solid

别名:

Dipeptidylpeptidase IV Inhibitor IV, K579, (S)-1-(4-Methyl-1-(2-pyrimidinyl)-4-piperidylamino)acetyl-2-pyrrolidinecarbonitrile, DPP IV Inhibitor IV

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关于此项目

经验公式（希尔记法）:
C17H24N6O
化学文摘社编号:
440100-64-1
分子量:
328.41
MDL number:
MFCD07364044
UNSPSC Code:
12352200
NACRES:
NA.77

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产品名称

Dipeptidylpeptidase IV Inhibitor IV, K579, The Dipeptidylpeptidase IV Inhibitor IV, K579, also referenced under CAS 440100-64-1, controls the biological activity of Dipeptidylpeptidase IV. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

SMILES string

N3([C@@H](CCC3)C#N)C(=O)CNC1(CCN(CC1)c2ncccn2)C

InChI

1S/C17H24N6O/c1-17(21-13-15(24)23-9-2-4-14(23)12-18)5-10-22(11-6-17)16-19-7-3-8-20-16/h3,7-8,14,21H,2,4-6,9-11,13H2,1H3/t14-/m0/s1

InChI key

JERPHRNGJBSFAP-AWEZNQCLSA-N

assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

off-white to light brown

solubility

1 M HCl: 16 mg/mL, DMSO: 32 mg/mL, ethanol: 6.5 mg/mL

shipped in

ambient

Quality Level

100

相关类别

General description

A cyanopyrrolidine compound that acts as a potent DPP IV inhibitor (IC50 = 3, 5, 8, and 8 nM in inhibiting rat, human, monkey, and canine DDP IV, respectively). Oral administration of K579 in rats in vivo has been shown to reduce blood DPP IV activity and augment GLP-1 and insulin response after glucose intake and significantly reduce plasma glucose concentration.
Please note: 328.4 is the anhydrous molecular weight; please refer to the vial label for the lot-specific hydration and molecular weight.

Packaging

Packaged under inert gas

Other Notes

Please note: 328.4 is the anhydrous molecular weight; please refer to the vial label for the lot-specific hydration and molecular weight.
Takasaki, K., et al. 2004. Eur. J. Pharmacol.505, 237.
Takasaki, K., et al. 2004. Eur. J. Pharmacol.486, 335.
Takasaki, K., et al. 2004. J. Pharmacol. Sci.95, 291.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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