317700
Dkk-1抑制剂，WAY-262611，HCl
The Dkk-1 Inhibitor, WAY-262611 controls the biological activity of Dkk-1.
别名:
Dkk-1抑制剂，WAY-262611，HCl
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关于此项目
经验公式（希尔记法）:
C20H22N4 · xHCl
分子量:
318.42 (free base basis)
NACRES:
NA.77
UNSPSC Code:
12352200
assay
≥95% (HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow
solubility
DMSO: 25 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
相关类别
General description
一种2-氨基嘧啶化合物，可抵消Dkk-1（Dickkopf-1）对Wnt-3a/LRP5交互效应的拮抗效应，并防止Dkk-1介导的KR2/LRP5/Dkk-1复合物的形成和内在化。已显示在体外存在Dkk-1（在基于细胞的TCF荧光素酶测定中EC50 = 0.63 µM）的情况下成功挽救了对Wnt-3a刺激的细胞反应，并在28天的时间内使OVX大鼠的胫骨小梁骨形成增加了一倍，体内口服剂量为10 mg/kg/天。
Packaging
用惰性气体包装
Other Notes
Pelletier, J.C., et al. 2009.J. Med. Chem.52, 6962.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Yifan Wu et al.
Immunity, 54(11), 2595-2610 (2021-09-11)
Fungal airway infection (airway mycosis) is an important cause of allergic airway diseases such as asthma, but the mechanisms by which fungi trigger asthmatic reactions are poorly understood. Here, we leverage wild-type and mutant Candida albicans to determine how this
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