317700
Dkk-1抑制剂，WAY-262611，HCl
The Dkk-1 Inhibitor, WAY-262611 controls the biological activity of Dkk-1.
别名:
Dkk-1抑制剂，WAY-262611，HCl
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关于此项目
经验公式（希尔记法）:
C20H22N4 · xHCl
分子量:
318.42 (free base basis)
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥95% (HPLC)
Form:
powder
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥95% (HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow
solubility
DMSO: 25 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
一种2-氨基嘧啶化合物，可抵消Dkk-1（Dickkopf-1）对Wnt-3a/LRP5交互效应的拮抗效应，并防止Dkk-1介导的KR2/LRP5/Dkk-1复合物的形成和内在化。已显示在体外存在Dkk-1（在基于细胞的TCF荧光素酶测定中EC50 = 0.63 µM）的情况下成功挽救了对Wnt-3a刺激的细胞反应，并在28天的时间内使OVX大鼠的胫骨小梁骨形成增加了一倍，体内口服剂量为10 mg/kg/天。
Packaging
用惰性气体包装
Other Notes
Pelletier, J.C., et al. 2009.J. Med. Chem.52, 6962.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable