324380
多柔比星盐酸盐-CAS 25316-40-9-Calbiochem
Doxorubicin HCl, CAS 25316-40-9, is an antitumor antibiotic that inhibits topoisomerase II (IC50 = 100 nM).
别名:
多柔比星盐酸盐-CAS 25316-40-9-Calbiochem
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关于此项目
经验公式（希尔记法）:
C27H29NO11 · xHCl
化学文摘社编号:
分子量:
543.52 (free base basis)
UNSPSC Code:
12352200
MDL number:
Quality Segment
assay
≥98% (HPLC)
form
powder
potency
100 nM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
orange to red
solubility
water: 10 mg/mL
shipped in
ambient
storage temp.
10-30°C
InChI
1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10?,13?,15-,17?,22?,27-;/m0./s1
InChI key
MWWSFMDVAYGXBV-FGBJBKNOSA-N
General description
抗肿瘤抗生素和抑制拓扑异构酶II（IC50=100 nM）的高效肌毒素。与核酸结合，大概是通过特异性插入DNA双螺旋中，从而抑制核酸合成。诱导横纹肌肉瘤细胞系的凋亡。也可以10 mM的H2O溶液（目录号504042）提供。
抗肿瘤抗生素和抑制拓扑异构酶II（IC50=100 nM）的高效肌毒素。与核酸结合，大概是通过特异性插入DNA双螺旋中，抑制核酸合成。细胞毒性似乎是由于其与DNA插入，与质膜相互作用以及参与氧化还原反应的能力。诱导横纹肌肉瘤细胞系的凋亡。
盐酸阿霉素，CAS 25316-40-9，是一种抑制拓扑异构酶II（IC₅₀=100 nM）的抗肿瘤抗生素。
Biochem/physiol Actions
主要靶标
拓扑异构酶2
拓扑异构酶2
产物不与ATP竞争。
Preparation Note
在复溶后冷藏（4°C）。储备液可在4°C最长稳定1个月。在酸性条件下，阿霉素被转化为水不溶性阿霉素和水溶性还原糖，六碳氨糖。
Other Notes
A′Hern, R.P., and Gore, M.E.1995.J. Clin. Oncol.13, 726.
Nooter, K., et al. 1995.Br. J. Cancer 71, 556.
Noviello, E., et al. 1994.Mutat.Res.311, 21.
Anderson, R.D., et al. 1993.Mutat.Res.294, 215.
Hershko, C., et al. 1993.J. Lab. Clin. Med.122, 245.
Jongmans, W., et al. 1993.Mutat.Res.294, 207.
O′Shaughnessy, J.A., and Cowan, K.H.1993.J. Am. Med. Assoc.270, 2089.
Theyer, G., et al. 1993.J. Urol.150, 1544.
Tritton, T.R., and Yee, G. 1982.Science217, 248.
Nooter, K., et al. 1995.Br. J. Cancer 71, 556.
Noviello, E., et al. 1994.Mutat.Res.311, 21.
Anderson, R.D., et al. 1993.Mutat.Res.294, 215.
Hershko, C., et al. 1993.J. Lab. Clin. Med.122, 245.
Jongmans, W., et al. 1993.Mutat.Res.294, 207.
O′Shaughnessy, J.A., and Cowan, K.H.1993.J. Am. Med. Assoc.270, 2089.
Theyer, G., et al. 1993.J. Urol.150, 1544.
Tritton, T.R., and Yee, G. 1982.Science217, 248.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：致癌/致畸（D）
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Carc. 1B - Muta. 1B - Repr. 1B
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable