324385
盐酸强力霉素
A commonly-used broad-spectrum antibiotic.
别名:
盐酸多西环素, α-6-脱氧-5-羟基四环素，强力霉素，多西环素
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C22H24N2O8 · 0.5H2O · 0.5C2H6O · xHCl
化学文摘社编号:
分子量:
476.48 (free base basis)
NACRES:
NA.77
UNSPSC Code:
12352200
MDL number:
产品名称
盐酸强力霉素, A commonly-used broad-spectrum antibiotic.
InChI
1S/2C22H24N2O8.C2H6O.2ClH.H2O/c2*1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;1-2-3;;;/h2*4-7,10,14-15,17,25-27,31-32H,23H2,1-3H3;3H,2H2,1H3;2*1H;1H2/b2*21-13+;;;;/t2*7-,10+,14+,15-,17-,22-;;;;/m00..../s1
InChI key
QDDHZFKCHWYXJF-PCLMCNLLSA-N
assay
≥98% (HPLC)
form
crystalline solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
color
yellow to yellow-green
solubility
water: 50 mg/mL
shipped in
ambient
storage temp.
2-8°C
Quality Level
Disclaimer
毒性：有害 & 致癌/致畸性（E）
Biochem/physiol Actions
主要靶标
MMP-8
MMP-8
产物不与ATP竞争。
可逆：否
细胞渗透性：否
靶标IC50：30 µM，针对MMP-8（中性粒细胞胶原酶）；25µM，抑制藻酸盐培养的牛关节软骨细胞胶原合成
General description
一种常用的广谱抗生素。相对于MMP-1（胶原酶-1；IC50 = 300 µM），MMP-8（中性粒细胞胶原酶；IC50 = 30 µM）的有效抑制剂。还抑制藻酸盐（IC50 = 25 µM）中培养的牛关节软骨细胞的胶原蛋白合成。通过LPS激活的巨噬细胞抑制一氧化氮的合成，而不影响IL-10的释放。
一种常用的广谱抗生素。相对于MMP-1（间质胶原酶；IC50 = 300 µM），MMP-8（中性粒细胞胶原酶；IC50 = 30 µM）的有效抑制剂。还抑制藻酸盐（IC50 = 25 µM）中培养的牛关节软骨细胞的胶原蛋白合成。通过LPS激活的巨噬细胞抑制一氧化氮的合成，而不影响IL-10的释放。
Other Notes
D’Agostino, P., et al. 1998.J. Infect.Dis.177, 489.
Beekman, B., et al. 1997.Biochem.Biophys.Res. Commun.237, 107.
Hanemaaijer, R., et al. 1997.J. Biol. Chem. 272, 31504.
Lauhio, A., et al. 1994.Clin. Exp.Immunol. Antimicrobiol.Agents Chemother.36, 227.
Sorsa, T., et al. 1994.Ann.N.Y.Acad.Sci.732, 112.
Suomalainen, K., et al. 1992.Antimicrobiol.Agents Chemother.36, 227.
Beekman, B., et al. 1997.Biochem.Biophys.Res. Commun.237, 107.
Hanemaaijer, R., et al. 1997.J. Biol. Chem. 272, 31504.
Lauhio, A., et al. 1994.Clin. Exp.Immunol. Antimicrobiol.Agents Chemother.36, 227.
Sorsa, T., et al. 1994.Ann.N.Y.Acad.Sci.732, 112.
Suomalainen, K., et al. 1992.Antimicrobiol.Agents Chemother.36, 227.
Preparation Note
在复溶后冷藏（4°C）。储备溶液在4°C下可稳定保存5天。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Warning
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Megan C Shepherd et al.
Cell communication and signaling : CCS, 19(1), 100-100 (2021-10-09)
Fetal cell-derived exosomes (extracellular vesicles, 40-160 nm) are communication channels that can signal parturition by inducing inflammatory changes in maternal decidua and myometrium. Little is known about maternal cell-derived exosomes and their functional roles on the fetal side. This study isolated
Hsiang-Chen Chou et al.
eLife, 10 (2021-02-02)
The origin recognition complex (ORC) cooperates with CDC6, MCM2-7, and CDT1 to form pre-RC complexes at origins of DNA replication. Here, using tiling-sgRNA CRISPR screens, we report that each subunit of ORC and CDC6 is essential in human cells. Using
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持