324410
Dynasore
≥98% (HPLC), solid, dynamin inhibitor, Calbiochem®
别名:
发动蛋白抑制剂I ，Dynasore
Product Name
发动蛋白抑制剂I ，Dynasore, The Dynamin Inhibitor I, Dynasore, also referenced under CAS 304448-55-3, controls the biological activity of Dynamin. This small molecule/inhibitor is primarily used for Membrane applications.
质量水平
方案
≥98% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
pale yellow
溶解性
DMSO: 16 mg/mL
运输
ambient
储存温度
2-8°C
SMILES字符串
N(\N=C\c3cc(c(cc3)O)O)C(=O)c1cc2c(cc1O)cccc2
InChI
1S/C18H14N2O4/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22/h1-10,21-23H,(H,20,24)/b19-10+
InChI key
SYNDQCRDGGCQRZ-VXLYETTFSA-N
相关类别
一般描述
一种细胞可渗透的缩氨基脲化合物，可抑制发动蛋白1/2（IC50 ~15 µM）和Drp1的GTPase活性，对其他两种小GTPases（MxA和Cdc42）没有显著的影响。Dynasore已被用来阐明发动蛋白在网格蛋白包被的和突触小泡介导的内吞作用中的作用。抑制相对于GTP是非竞争性的，并且抑制剂靶位点可能位于GTPase结构域中。显示抑制从质膜上去除wt和ΔF508-CFTR。
包装
用惰性气体包装
制备说明
复溶后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多3个月。
其他说明
Young, A., et al. 2009.Biochem.J., In press.
Nankoe, S.R., and Sever, S. 2006.Trends Cell Biol.16, 607.
Newton, A.J., et al. 2006.Proc.Natl.Acad.Sci. USA103, 17955.
Macia.E., et al. 2006.Dev.Cell10, 839.
Nankoe, S.R., and Sever, S. 2006.Trends Cell Biol.16, 607.
Newton, A.J., et al. 2006.Proc.Natl.Acad.Sci. USA103, 17955.
Macia.E., et al. 2006.Dev.Cell10, 839.
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法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
毒性：环境危害（N）
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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