324411
Dynamin Inhibitor II, MiTMAB
The Dynamin Inhibitor II, MiTMAB, also referenced under CAS 1119-97-7, controls the biological activity of Dynamin. This small molecule/inhibitor is primarily used for Membrane applications.
别名:
Dynamin Inhibitor II, MiTMAB, Tetradecyl trimethyl ammonium Bromide, Myr istyl tri methyl ammonium Bromide, TTAB
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关于此项目
经验公式（希尔记法）:
C17H38BrN
化学文摘社编号:
分子量:
336.39
UNSPSC Code:
41121801
NACRES:
NA.77
MDL number:
SMILES string
[Br-].[N+](CCCCCCCCCCCCCC)(C)(C)C
InChI
1S/C17H38N.BrH/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18(2,3)4;/h5-17H2,1-4H3;1H/q+1;/p-1
InChI key
CXRFDZFCGOPDTD-UHFFFAOYSA-M
description
Merck USA index - 14, 6336
assay
≥99% (titration)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic)
color
white
solubility
DMSO: 10 mg/mL, water: 100 mg/mL
shipped in
ambient
Quality Level
General description
A cell-permeable cationic surfactant that reversibly inhibits dynamin GTPase activity (IC50 = 3.15 µM) by targeting the PH domain and interfering with phospholipid binding. Shown to block dynamin I-dependent SVE (synaptic vesicle endocytosis) in rat brain synaptosomes and dynamin II-dependent RME (receptor-mediated endocytosis) in non-neuronal HeLa, A431, and COS-7 cells. Inhibition is competitive with respect to PS and noncompetitive with respect to GTP.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Quan, A., et al. 2007. Mol. Pharmacol.72, 1425.
Hill, T.A., et al. 2004. Bioorg. Med. Chem. Lett.14, 3275.
Hill, T.A., et al. 2004. Bioorg. Med. Chem. Lett.14, 3275.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Corrosive (L)
signalword
Danger
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Irrit. 2 - STOT RE 2 Oral - STOT SE 3
target_organs
Gastrointestinal tract, Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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