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Merck
CN

324517

4EGI-1

≥98% (sum of two isomers, HPLC), eIF4E inhibitor, solid

别名:

eIF4E/eIF4G Interaction Inhibitor, 4EGI-1, 2-((4-(3,4-Dichlorophenyl)-thiazol-2-ylhydrazono)-3-(2-nitrophenyl))propionic acid, eIF4F Inhibitor I

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关于此项目

经验公式（希尔记法）:
C18H12Cl2N4O4S
化学文摘社编号:
315706-13-9
分子量:
451.28
MDL编号:
MFCD10565943
UNSPSC代码:
12352200
NACRES:
NA.77

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产品名称

eIF4E/eIF4G Interaction Inhibitor, 4EGI-1, The eIF4E/eIF4G Interaction Inhibitor, 4EGI-1, also referenced under CAS 315706-13-9, controls the biological activity of eIF4E/eIF4G interaction. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

质量水平

100

方案

≥98% (sum of two isomers, HPLC)

表单

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
protect from light

颜色

yellow

溶解性

DMSO: 100 mg/mL

运输

ambient

储存温度

2-8°C

InChI

1S/C18H12Cl2N4O4S/c19-12-6-5-10(7-13(12)20)15-9-29-18(21-15)23-22-14(17(25)26)8-11-3-1-2-4-16(11)24(27)28/h1-7,9H,8H2,(H,21,23)(H,25,26)/b22-14+

InChI key

KFRKRECSIYXARE-HYARGMPZSA-N

相关类别

一般描述

A cell-permeable hydrazone compound that reversibly binds eukaryotic translation initiation factor 4E (eIF4E; KD = 25 µM) and disrupts eIF4E/eIF4G, but not eIF4E/4E-BP1, complex formation. Reported to downregulate the protein, but not mRNA, levels of c-Myc and Bcl-xL in Jurkat cells (8 h), leading to apoptotic cell death after prolonged exposure (24 h, IC50 = ~ 25 µM). Also available as a 25 mM solution in DMSO (Cat. No. 324519).

包装

Packaged under inert gas

制备说明

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Moerke, N. J., et al. 2007. Cell128, 257.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Toxicity: Harmful (C)

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

677.1 °F - (calculated)

闪点(°C)

358.4 °C - (calculated)

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