324519
eIF4E/eIF4G Interaction Inhibitor, 4EGI-1
InSolution, ≥95%, reversibly binds eukaryotic translation initiation factor 4E
别名:
InSolution eIF4E/eIF4G Interaction Inhibitor, 4EGI-1, 2-((4-(3,4-Dichlorophenyl)-thiazol-2-ylhydrazono)-3-(2-nitrophenyl))propionic acid, eIF4F Inhibitor I, eIF4F Inhibitor I, 2-((4-(3,4-Dichlorophenyl)-thiazol-2-ylhydrazono)-3-(2-nitrophenyl))propionic acid
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关于此项目
经验公式（希尔记法）:
C18H12Cl2N4O4S
化学文摘社编号:
分子量:
451.28
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
InChI
1S/C18H12Cl2N4O4S/c19-12-6-5-10(7-13(12)20)15-9-29-18(21-15)23-22-14(17(25)26)8-11-3-1-2-4-16(11)24(27)28/h1-7,9H,8H2,(H,21,23)(H,25,26)/b22-14+
InChI key
KFRKRECSIYXARE-HYARGMPZSA-N
assay
≥95% (sum of two isomers, HPLC)
form
liquid
potency
25 μM Ki
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, avoid repeated freeze/thaw cycles, desiccated (hygroscopic), protect from light
shipped in
dry ice
storage temp.
−70°C
Quality Level
General description
A cell-permeable hydrazone compound that reversibly binds eukaryotic translation initiation factor 4E (eIF4E; KD = 25 µM) and disrupts eIF4E/eIF4G, but not eIF4E/4E-BP1, complex formation. Reported to downregulate the protein, but not mRNA, levels of c-Myc and Bcl-xL in Jurkat cells (8 hrs), leading to apoptotic cell death after prolonged exposure (24 hrs, IC50 ~25 µM). Shown to be brain permeant and reduce neuroligin protein levels, and restore L-LTP threshold and rescue autistic-like behaviours in Eif4ebp2 knockout mice.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
eIF4E
eIF4E
Reversible: yes
Packaging
Packaged under inert gas
Physical form
A 25 mM (5 mg/443 µL) solution of eIF4E/eIF4G Interaction Inhibitor, 4EGI-1 (Cat. No. 324517)
Preparation Note
Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
Other Notes
Gkogkas, C.G., et al. 2012. Nature493, 371.
Moerke, N. J., et al. 2007. Cell128, 257.
Moerke, N. J., et al. 2007. Cell128, 257.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Reversal of memory and autism-related phenotypes in Tsc2+/- mice via inhibition of Nlgn1.
Chalkiadaki, et al.
Frontiers in Cell and Developmental Biology, 11, 1205112-1205112 (2023)
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