324694
Emodin
A cell-permeable, reversible, substrate competitive and potent p56lck tyrosine kinase inhibitor (IC50 = 18.5 µM).
别名:
Emodin, 6-Methyl-1,3,8-trihydroxyanthraquinone
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关于此项目
经验公式（希尔记法）:
C15H10O5
化学文摘社编号:
分子量:
270.24
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
Emodin, A cell-permeable, reversible, substrate competitive and potent p56lck tyrosine kinase inhibitor (IC50 = 18.5 µM).
SMILES string
Oc1c2c(cc(c1)O)C(=O)c3c(c(cc(c3)C)O)C2=O
InChI
1S/C15H10O5/c1-6-2-8-12(10(17)3-6)15(20)13-9(14(8)19)4-7(16)5-11(13)18/h2-5,16-18H,1H3
InChI key
RHMXXJGYXNZAPX-UHFFFAOYSA-N
description
Merck USA index - 14, 3561
assay
≥90% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
orange
solubility
DMSO: 1 mg/mL
aqueous base: soluble
ethanol: soluble
shipped in
ambient
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Cell permeable: yes
Primary Target
p56lck tyrosine kinase
p56lck tyrosine kinase
Product does not compete with ATP.
Reversible: yes
Target IC50: 18.5 µM against p56lck tyrosine kinase
Disclaimer
Toxicity: Standard Handling (A)
General description
A cell-permeable, reversible, substrate competitive and potent p56lck tyrosine kinase inhibitor (IC50 = 18.5 µM). Selectively blocks the growth of v-ras transformed human bronchial epithelial cells (IC50 = 14.8 µM) without affecting normal human bronchial epithelial cells, even at a concentration of 370 mM. Reported to act as an inhibitor of Tau aggregation and aid in the disassembly of PHF in vitro and in vivo.
Other Notes
Pickhardt, M., et al. 2004. J. Biol. Chem.280, 3628.
Zhang, L., and Hung. M.C. 1996. Oncogene 12, 571.
Chan, T.C., et al. 1993. Biochem. Biophys. Res. Commun. 193, 1152.
Jayasuriya, H., et al. 1992. J. Nat. Prod.55, 696.
Zhang, L., and Hung. M.C. 1996. Oncogene 12, 571.
Chan, T.C., et al. 1993. Biochem. Biophys. Res. Commun. 193, 1152.
Jayasuriya, H., et al. 1992. J. Nat. Prod.55, 696.
Preparation Note
Following reconstitution in DMSO, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 3 months at -20°C. Unstable in aqueous alkali; reconstitute just prior to use.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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