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Merck
CN

324696

Millipore

Methoxysuccinyl-Ala-Ala-Pro-Val-p-nitroanilide

A specific chromogenic substrate for human neutrophil elastase.

别名:

Elastase Substrate I, Colorimetric

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关于此项目

经验公式（希尔记法）:
C27H38N6O9
CAS Number:
70967-90-7
分子量:
590.63
MDL编号:
MFCD00077137
UNSPSC代码:
12352200
NACRES:
NA.54

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Product Name

Elastase Substrate I, Colorimetric, A specific chromogenic substrate for human neutrophil elastase.

质量水平

100

方案

≥95% (HPLC)

表单

lyophilized

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
desiccated

溶解性

water: 1 mg/mL

运输

ambient

储存温度

−20°C

SMILES字符串

[N+](=O)([O-])c1ccc(cc1)N[C@@H](C(C)C)C(=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](NC(=O)[C@@H](NC(=O)CCC(=O)OC)C)C

InChI

1S/C27H38N6O9/c1-15(2)23(30-18-8-10-19(11-9-18)33(40)41)26(38)31-25(37)20-7-6-14-32(20)27(39)17(4)29-24(36)16(3)28-21(34)12-13-22(35)42-5/h8-11,15-17,20,23,30H,6-7,12-14H2,1-5H3,(H,28,34)(H,29,36)(H,31,37,38)/t16-,17-,20-,23-/m0/s1

InChI key

JWYKDZIEIWGSBN-OSAZLGQLSA-N

相关类别

一般描述

A specific chromogenic substrate for human neutrophil elastase (Kcat/Km = 120,000 vs. 2700 for pancreatic elastase). Cleavage can be monitored at ~410 nm. Sold on the basis of substrate content.
Specific chromogenic substrate for human neutrophil elastase (kcat/Km = 120,000 versus pancreatic elastase: kcat/Km = 2,700). Cleavage can be monitored at 410 nm using ε = 8,800.

生化/生理作用

Cell permeable: no
Kcat/Km = 120,000 vs. 2700 for pancreatic elastase
Primary Target
Chromogenic substrate for human neutrophil elastase
Product does not compete with ATP.
Reversible: no

外形

Lyophilized from a solution containing 90 mg D-mannitol and 10 mg substrate.

制备说明

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Barrett, A.J., et al. 1989. Biochim. J.260, 259.
Nakajima, K., et al. 1979. J. Biol. Chem.254, 4027.
MeOSuc-Ala-Ala-Pro-Val-pNA

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Toxicity: Standard Handling (A)

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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Ning Luan et al.
Toxins, 11(12) (2019-12-11)
Elastase is a globular glycoprotein and belongs to the chymotrypsin family. It is involved in several inflammatory cascades on the basis of cleaving the important connective tissue protein elastin, and is strictly regulated to a balance by several endogenous inhibitors.

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