General description
Cell permeable: No
Product does not compete with ATP.
Reversible: No
Epoxomicin is a highly effective and selective proteasome inhibitor thatexhibits significant anti-inflammatory properties in vivo. This potent antitumor agent specifically targets the proteasome. Epoxomicin exhibits a stronger inhibitory effect on chymotrypsin-like activity compared to lactacystin and the peptide vinyl sulfone (NLVS). This powerful natural producteffectively inhibits nuclear factor kappa B (NF-κB) activation in vitro and signific antly reduces inflammation in the murine ear edema assay. Epoxomicin prevents the degradation of IκB and inhibits the activation of NF-κBDNA-binding activity. It can stabilize p53 levels in cell culture. It is an irreversible inhibitor of chymotrypsin-like (CT-L), trypsin-like (T-L), and peptidylglutamyl peptide hydrolyzing (PGPH) activities of the proteasome. It modifies the proteasomal catalytic subunits LMP-7, MECL1, and Z[MJ2] .
Product does not compete with ATP.
Reversible: No
Epoxomicin is a highly effective and selective proteasome inhibitor thatexhibits significant anti-inflammatory properties in vivo. This potent antitumor agent specifically targets the proteasome. Epoxomicin exhibits a stronger inhibitory effect on chymotrypsin-like activity compared to lactacystin and the peptide vinyl sulfone (NLVS). This powerful natural producteffectively inhibits nuclear factor kappa B (NF-κB) activation in vitro and signific antly reduces inflammation in the murine ear edema assay. Epoxomicin prevents the degradation of IκB and inhibits the activation of NF-κBDNA-binding activity. It can stabilize p53 levels in cell culture. It is an irreversible inhibitor of chymotrypsin-like (CT-L), trypsin-like (T-L), and peptidylglutamyl peptide hydrolyzing (PGPH) activities of the proteasome. It modifies the proteasomal catalytic subunits LMP-7, MECL1, and Z[MJ2] .
Application
Epoxomicin has been used incell culture for proteasome inhibition experiments. It has also been used incell culture medium to treat MODE-K cells for stimulation to blockproteasome.
Packaging
用惰性气体包装
Physical form
合成环氧酶素（目录号 324800）在DMSO中的1 mM（50 µg/90 µl）溶液。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：刺激性（B）
存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
188.6 °F - closed cup - (Dimethylsulfoxide)
flash_point_c
87 °C - closed cup - (Dimethylsulfoxide)
Trim-Away ubiquitinates and degrades lysine-less and N-terminally acetylated substrates.
Kiss, et al.
Nature Communications, 14, 2160-2160 (2023)
Giulia Pontarollo et al.
Nature metabolism, 5(7), 1174-1187 (2023-07-07)
The gut microbiota influences intestinal barrier integrity through mechanisms that are incompletely understood. Here we show that the commensal microbiota weakens the intestinal barrier by suppressing epithelial neuropilin-1 (NRP1) and Hedgehog (Hh) signaling. Microbial colonization of germ-free mice dampens signaling
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