324801
环氧霉素(Epoxomicin)
≥95% (HPLC), liquid, proteasome inhibitor, Calbiochem®
别名:
InSolution环氧酶素，合成
登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
经验公式（希尔记法）:
C28H50N4O7
分子量:
554.72
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
liquid
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
产品名称
环氧霉素(Epoxomicin), InSolution, ≥95%
Quality Segment
assay
≥95% (HPLC)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
shipped in
wet ice
storage temp.
−20°C
General description
Cell permeable: No
Product does not compete with ATP.
Reversible: No
Epoxomicin is a highly effective and selective proteasome inhibitor thatexhibits significant anti-inflammatory properties in vivo. This potent antitumor agent specifically targets the proteasome. Epoxomicin exhibits a stronger inhibitory effect on chymotrypsin-like activity compared to lactacystin and the peptide vinyl sulfone (NLVS). This powerful natural producteffectively inhibits nuclear factor kappa B (NF-κB) activation in vitro and signific antly reduces inflammation in the murine ear edema assay. Epoxomicin prevents the degradation of IκB and inhibits the activation of NF-κBDNA-binding activity. It can stabilize p53 levels in cell culture. It is an irreversible inhibitor of chymotrypsin-like (CT-L), trypsin-like (T-L), and peptidylglutamyl peptide hydrolyzing (PGPH) activities of the proteasome. It modifies the proteasomal catalytic subunits LMP-7, MECL1, and Z[MJ2] .
Product does not compete with ATP.
Reversible: No
Epoxomicin is a highly effective and selective proteasome inhibitor thatexhibits significant anti-inflammatory properties in vivo. This potent antitumor agent specifically targets the proteasome. Epoxomicin exhibits a stronger inhibitory effect on chymotrypsin-like activity compared to lactacystin and the peptide vinyl sulfone (NLVS). This powerful natural producteffectively inhibits nuclear factor kappa B (NF-κB) activation in vitro and signific antly reduces inflammation in the murine ear edema assay. Epoxomicin prevents the degradation of IκB and inhibits the activation of NF-κBDNA-binding activity. It can stabilize p53 levels in cell culture. It is an irreversible inhibitor of chymotrypsin-like (CT-L), trypsin-like (T-L), and peptidylglutamyl peptide hydrolyzing (PGPH) activities of the proteasome. It modifies the proteasomal catalytic subunits LMP-7, MECL1, and Z[MJ2] .
Application
Epoxomicin has been used incell culture for proteasome inhibition experiments. It has also been used incell culture medium to treat MODE-K cells for stimulation to blockproteasome.
Packaging
用惰性气体包装
Physical form
合成环氧酶素（目录号 324800）在DMSO中的1 mM（50 µg/90 µl）溶液。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：刺激性（B）
Still not finding the right product?
Explore all of our products under 环氧霉素(Epoxomicin)
存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
188.6 °F - closed cup - (Dimethylsulfoxide)
flash_point_c
87 °C - closed cup - (Dimethylsulfoxide)