324813
Soluble Epoxide Hydrolase Inhibitor, NCND
The Soluble Epoxide Hydrolase Inhibitor, NCND, also referenced under CAS 402939-18-8, controls the biological activity of Soluble Epoxide Hydrolase.
别名:
Soluble Epoxide Hydrolase Inhibitor, NCND, CDU, N-Cyclohexyl-Nʹ-dodecylurea, 1-Cyclohexyl-3ʹ-dodecylurea
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关于此项目
经验公式（希尔记法）:
C19H38N2O
化学文摘社编号:
分子量:
310.52
MDL number:
UNSPSC Code:
12352202
NACRES:
NA.54
产品名称
Soluble Epoxide Hydrolase Inhibitor, NCND, The Soluble Epoxide Hydrolase Inhibitor, NCND, also referenced under CAS 402939-18-8, controls the biological activity of Soluble Epoxide Hydrolase.
SMILES string
N(C1CCCCC1)C(=O)NCCCCCCCCCCCC
InChI
1S/C19H38N2O/c1-2-3-4-5-6-7-8-9-10-14-17-20-19(22)21-18-15-12-11-13-16-18/h18H,2-17H2,1H3,(H2,20,21,22)
InChI key
POEWFBSYPFIYSK-UHFFFAOYSA-N
assay
≥95% (TLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
dichloromethane: 1 mg/mL
shipped in
ambient
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Soluble epoxide hydrolase
Soluble epoxide hydrolase
Product competes with ATP.
Reversible: no
Target IC50: 9.8 nM for mouse recombinant sEH, 85.2 nM for human recombinant sEH
Disclaimer
Toxicity: Standard Handling (A)
General description
A cell-permeable 1,3-disubstituted urea compound that displays anti-hypertensive and anti-inflammatory properties. Acts as a potent, selective, competitive, and tight-binding transition-state analog inhibitor of soluble epoxide hydrolase (sEH; IC50 = 9.8 nM for mouse recombinant sEH, 85.2 nM for human recombinant sEH). Reported to decrease human VSMC (vascular smooth muscle cell) proliferation.
A cell-permeable, potent, selective, competitive, and tight binding transition-state analog inhibitor of soluble epoxide hydrolase (sEH) (IC50 = 9.8 nM for recombinant murine sEH and 85.2 nM for recombinant human sEH). Also displays anti-hypertensive and anti-inflammatory properties. Reported to decrease human vascular smmoth muscle cell (VSMC) proliferation.
Other Notes
Newman, J.W., et al. 2003. Proc. Natl. Acad. Sci. USA100, 1558.
Davis, B.B., et al. 2002. Proc. Natl. Acad. Sci. USA99, 2222.
Morisseau, C., et al. 2002. Biochem. Pharmacol.63, 1599.
Imig, J.D., et al. 2002. Hypertension39, 690.
Argiriadi, M.A., et al. 2000. J. Biol. Chem.275, 15265.
Yu, Z., et al. 2000. Circ. Res.87, 992.
Davis, B.B., et al. 2002. Proc. Natl. Acad. Sci. USA99, 2222.
Morisseau, C., et al. 2002. Biochem. Pharmacol.63, 1599.
Imig, J.D., et al. 2002. Hypertension39, 690.
Argiriadi, M.A., et al. 2000. J. Biol. Chem.275, 15265.
Yu, Z., et al. 2000. Circ. Res.87, 992.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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