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324813

Soluble Epoxide Hydrolase Inhibitor, NCND

Name: Soluble Epoxide Hydrolase Inhibitor, NCND
Brand: MM

The Soluble Epoxide Hydrolase Inhibitor, NCND, also referenced under CAS 402939-18-8, controls the biological activity of Soluble Epoxide Hydrolase.

别名:

Soluble Epoxide Hydrolase Inhibitor, NCND, CDU, N-Cyclohexyl-Nʹ-dodecylurea, 1-Cyclohexyl-3ʹ-dodecylurea

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关于此项目

经验公式（希尔记法）:

C₁₉H₃₈N₂O

化学文摘社编号:

402939-18-8

分子量:

310.52

MDL number:

MFCD01344729

UNSPSC Code:

12352202

NACRES:

NA.54

Assay:

≥95% (TLC)

Form:

solid

Quality level:

100

Storage condition:

OK to freeze

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属性

Quality Level

100

assay

≥95% (TLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

color

white

solubility

dichloromethane: 1 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

N(C1CCCCC1)C(=O)NCCCCCCCCCCCC

InChI

1S/C19H38N2O/c1-2-3-4-5-6-7-8-9-10-14-17-20-19(22)21-18-15-12-11-13-16-18/h18H,2-17H2,1H3,(H2,20,21,22)

InChI key

POEWFBSYPFIYSK-UHFFFAOYSA-N

说明

General description

A cell-permeable 1,3-disubstituted urea compound that displays anti-hypertensive and anti-inflammatory properties. Acts as a potent, selective, competitive, and tight-binding transition-state analog inhibitor of soluble epoxide hydrolase (sEH; IC₅₀ = 9.8 nM for mouse recombinant sEH, 85.2 nM for human recombinant sEH). Reported to decrease human VSMC (vascular smooth muscle cell) proliferation.

A cell-permeable, potent, selective, competitive, and tight binding transition-state analog inhibitor of soluble epoxide hydrolase (sEH) (IC₅₀ = 9.8 nM for recombinant murine sEH and 85.2 nM for recombinant human sEH). Also displays anti-hypertensive and anti-inflammatory properties. Reported to decrease human vascular smmoth muscle cell (VSMC) proliferation.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Soluble epoxide hydrolase

Product competes with ATP.

Reversible: no

Target IC₅₀: 9.8 nM for mouse recombinant sEH, 85.2 nM for human recombinant sEH

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Newman, J.W., et al. 2003. Proc. Natl. Acad. Sci. USA100, 1558.
Davis, B.B., et al. 2002. Proc. Natl. Acad. Sci. USA99, 2222.
Morisseau, C., et al. 2002. Biochem. Pharmacol.63, 1599.
Imig, J.D., et al. 2002. Hypertension39, 690.
Argiriadi, M.A., et al. 2000. J. Biol. Chem.275, 15265.
Yu, Z., et al. 2000. Circ. Res.87, 992.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c