328000
ERK活化抑制剂肽I，细胞可渗透
The ERK Activation Inhibitor Peptide I, Cell-Permeable controls the biological activity of ERK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
ERK活化抑制剂肽I，细胞可渗透
产品名称
ERK活化抑制剂肽I，细胞可渗透, The ERK Activation Inhibitor Peptide I, Cell-Permeable controls the biological activity of ERK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
assay
≥95% (HPLC)
form
lyophilized solid
potency
2.5 μM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
protect from light
color
white
solubility
water: 1 mg/mL
DMSO: 5 mg/mL
shipped in
wet ice
storage temp.
−20°C
Quality Level
相关类别
Biochem/physiol Actions
主要靶标
MEK
MEK
产物不与ATP竞争。
可逆性：是
细胞可渗透性：是
Disclaimer
毒性：标准处理（A）
General description
一种细胞可渗透且可逆硬脂酸的13-氨基酸的肽，对应于MEK1（MAPKK）的N末端，可作为ERK激活的特异性抑制剂，并阻断Elk1的转录活性。选择性地与ERK2结合，并阻止其与MEK的交互效应（IC50 = 2.5 µM）。可有效阻断在PMA刺激的NIH 3T3细胞和NGF处理的PC12细胞（IC50 = 13 µM）中的ERK活性。不影响JNKs或p38的活性。
一种细胞可渗透的，可逆和硬脂酸的13-氨基酸肽，对应于MAPK/ERK激酶（MEK）的N末端。作为ERK激活的特异性抑制剂，并阻断ELK1的转录活性。选择性地与ERK2结合，并阻止其与MEK的交互效应（IC50 = 2.5 µM）。显示可阻断在PMA刺激的NIH3T3细胞和NGF处理的PC12细胞（IC50 = 13 µM）中的ERK活性。不影响JNKs或p38 MAP激酶的活性。
Other Notes
Kelemen, B.R., et al. 2002.J. Biol. Chem.277, 8741.
Ste-Met-Pro-Lys-Lys-Lys-Pro-Thr-Pro-Ile-Gln-Leu-Asn-Pro-NH₂（Ste = 硬脂酸的）
Packaging
用惰性气体包装
Physical form
作为三氟乙酸盐提供。
Preparation Note
复溶后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多3个月。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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