329600
Erastin
≥98% (HPLC), solid, ferroptosis inducer, Calbiochem®
别名:
Erastin, 2-（1-（4-（2-（4-氯苯氧基）乙酰基）-哌嗪-1-基）-乙基）-3-（2-乙氧基苯基）-3H-喹唑啉-4-酮
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关于此项目
经验公式（希尔记法）:
C30H31ClN4O4
化学文摘社编号:
分子量:
547.04
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
Erastin, A cell-permeable piperazinyl-quinazolinone compound that exhibits oncogene-selective lethality.
SMILES string
Clc1ccc(cc1)OCC(=O)N2CCN(CC2)C(C)c3[n]([c](c5c(n3)cccc5)=O)c4c(cccc4)OCC
InChI
1S/C30H31ClN4O4/c1-3-38-27-11-7-6-10-26(27)35-29(32-25-9-5-4-8-24(25)30(35)37)21(2)33-16-18-34(19-17-33)28(36)20-39-23-14-12-22(31)13-15-23/h4-15,21H,3,16-20H2,1-2H3
InChI key
BKQFRNYHFIQEKN-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
white
solubility
DMSO: 50 mg/mL
shipped in
wet ice
storage temp.
−20°C
Quality Level
Packaging
用惰性气体包装
Preparation Note
复溶后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多6个月。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
General description
具有致癌基因选择性杀伤力的细胞可渗透的哌嗪基-喹唑啉酮化合物。显示结合线粒体电压依赖性阴离子通道（VDAC）并改变其门控；在几种人类肿瘤中快速诱导氧化性，非凋亡性细胞死亡，这些肿瘤在RAS-RAF-MEK信号传导中具有激活突变（在BJ-TERT/LT/ST/RASV12细胞中EC50 = 6.0 µM）。
Other Notes
Yagoda, N., et al. 2007.Nature447, 864.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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