产品名称
N-乙基马来酰亚胺, Sulfhydryl alkylating reagent that inhibits H+-ATPase and suppresses the short circuit current (IC50 = 22 µM) in pancreatic duct cells.
SMILES string
N1(C(=O)C=CC1=O)CC
InChI
1S/C6H7NO2/c1-2-7-5(8)3-4-6(7)9/h3-4H,2H2,1H3
InChI key
HDFGOPSGAURCEO-UHFFFAOYSA-N
description
Merck USA index - 14, 3822
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
ethanol: 5 mg/mL
storage temp.
10-30°C
Quality Level
Biochem/physiol Actions
主要靶标
H+-ATPase
H+-ATPase
靶标IC50：22 µM，用于抑制短路电流
Disclaimer
毒性：腐蚀性（L）
General description
巯基烷基化试剂。已用于阻断干扰葡萄糖氧化酶测定的含巯基试剂。灭活NADP依赖性异柠檬酸脱氢酶。核酸内切酶抑制剂。也是大鼠肝核中Mg2+和Ca2+/Mg2+刺激的DNA片段化的有效抑制剂。
抑制H+-ATPase并抑制胰腺导管细胞短路电流（IC50 = 22 µM）的巯基烷基化试剂。灭活NADP依赖性异柠檬酸脱氢酶。也是大鼠肝核中Mg2+和Ca2+/Mg2+刺激的DNA片段化的有效抑制剂。通过激活内皮细胞中的PLA2刺激花生四烯酸释放。
Other Notes
Huang, Y.C., et al. 1995.Arch.Biochem.Biophys.316, 485.
Neve, E.P.A., et al. 1995.Biochem.Pharmacol.49, 57.
Cain, K., et al. 1994.Biochem.Cell Biol.72, 631.
Banger, K.K., et al. 1993.Biochem.J. 290, 199.
Mattingly, J.R., Jr., et al. 1993.J. Biol. Chem. 268, 3925.
Neve, E.P.A., et al. 1995.Biochem.Pharmacol.49, 57.
Cain, K., et al. 1994.Biochem.Cell Biol.72, 631.
Banger, K.K., et al. 1993.Biochem.J. 290, 199.
Mattingly, J.R., Jr., et al. 1993.J. Biol. Chem. 268, 3925.
Preparation Note
复溶后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多3个月。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral - Acute Tox. 3 Dermal - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
163.2 °F - closed cup
flash_point_c
72.9 °C - closed cup
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