Exotoxin A, Pseudomonas aeruginosa - CAS 91262-95-2 - Calbiochem

Shown to inhibit protein synthesis through ADP-ribosylation of elongation factor 2. Cytopathic for a number of cell lines and exhibits toxicity in animals. Has enzymatic activity identical to that of diphtheria toxin, however it has distinct target-cell specificities and is immunologically unrelated.

Shown to inhibit protein synthesis through ADP-ribosylation of elongation factor 2. Cytopathic for a number of cell lines and exhibits toxicity in animals. Has enzymatic activity identical to that of diphtheria toxin; however, it has distinct target-cell specificity and is immunologically unrelated.

Cell permeable: no

Primary Target
ADP-ribosylation of elongation factor 2

Product does not compete with ATP.

Reversible: no

Solid lyophilized from 150 mM NaCl, 10 mM sodium phosphate buffer, pH 7.5.

Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 2 weeks at 4°C or for up to 6 months at -20°C.

Single band by SDS-PAGE; single precipitin band by immunodiffusion

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Prentice, G.A., and Merrill, A.R. 1999. Anal. Biochem. 272, 216.

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Toxicity: Highly Toxic (H)