FAAH Inhibitor III, URB937

A blood-brain-barrier impermeable p-hydroxyphenylcarbamate compound that acts as a potent and irreversible inhibitor of FAAH activity (IC₅₀ = 26.8 nM rat brain) with excellent selectivity over monoacylglycerol lipases (IC₅₀ >100 µM). Shown to rapidly block mouse liver FAAH activity over brain (ED₅₀ = 0.2 mg/kg vs. 40 mg/kg, s.c.), elevate anandamide and palmitoylethanolamide levels in peripheral tissues (1 mg/kg, i.p.) and exert antinociceptive action. The CNS-penetrant FAAH Inhibitor II, URB597 is also available (Cat. No. 341249 ).

Packaged under inert gas

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Clapper, J.R., et al. 2010. Nat. Neurosci.13, 1265.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Toxicity: Standard Handling (A)