341608
FGF Receptor Tyrosine Kinase Inhibitor
The FGF Receptor Tyrosine Kinase Inhibitor, also referenced under CAS 192705-79-6, controls the biological activity of FGF Receptor Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
FGF Receptor Tyrosine Kinase Inhibitor, 1-(2-Amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-tert-butyl urea, PD 166866, PD 166866, 1-(2-Amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-tert-butyl urea
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关于此项目
经验公式（希尔记法）:
C20H24N6O3
化学文摘社编号:
分子量:
396.44
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
SMILES string
N(C(C)(C)C)C(=O)Nc1nc2nc(ncc2cc1c3cc(cc(c3)OC)OC)N
InChI
1S/C20H24N6O3/c1-20(2,3)26-19(27)25-17-15(8-12-10-22-18(21)24-16(12)23-17)11-6-13(28-4)9-14(7-11)29-5/h6-10H,1-5H3,(H4,21,22,23,24,25,26,27)
InChI key
NHJSWORVNIOXIT-UHFFFAOYSA-N
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
DMSO: 10 mg/mL
shipped in
ambient
Quality Level
General description
A cell-permeable pyridopyrimidinyl urea compound that acts a potent, ATP-competitive inhibitor of FGFR (IC50 = 60 nM using FGFR1) with excellent selectivity over PDGFRβ, EGFR, insulin receptor, and c-Src (IC50 >50 µM).
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Panek, R.L., et al. 1998. J. Pharm. Exp. Ther.286, 569.
Hamby, J.M., et al. 1997. J. Med. Chem.40, 2296.
Hamby, J.M., et al. 1997. J. Med. Chem.40, 2296.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Alexander S Brown et al.
Development (Cambridge, England), 138(18), 3967-3976 (2011-08-13)
In mouse embryos lacking sonic hedgehog (Shh), dorsoventral polarity within the otic vesicle is disrupted. Consequently, ventral otic derivatives, including the cochlear duct and saccule, fail to form, and dorsal otic derivatives, including the semicircular canals, endolymphatic duct and utricle
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