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About This Item
经验公式(希尔记法):
C16H11N3O2
CAS Number:
分子量:
277.28
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.77
质量水平
方案
≥95% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
off-white
溶解性
DMSO: 5 mg/mL
运输
ambient
储存温度
2-8°C
SMILES字符串
[nH]1c2c(nc1c3c(nc4c(c3O)cccc4)O)cccc2
InChI
1S/C16H11N3O2/c20-14-9-5-1-2-6-10(9)19-16(21)13(14)15-17-11-7-3-4-8-12(11)18-15/h1-8H,(H,17,18)(H2,19,20,21)
InChI key
YXCWBNCDJZEBKY-UHFFFAOYSA-N
一般描述
A cell-permeable benzimidazolo-hydroquinolinone compound that acts as a potent, reversible, ATP-competitive inhibitor against PDGFRβ, FGFR-1, and VEGFR-2 (IC50 = 20, 90, and 240 nM, respectively) and effectively suppresses VEGF-stimulated proliferation of HMVECs (EC50 = 420 nM).
包装
Packaged under inert gas
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Renhowe, P.A., et al. 2009. J. Med. Chem.52, 278.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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