341631
Bovine Fibronectin
from bovine plasma, liquid, suitable for cell culture
别名:
纤连蛋白，牛血浆
产品名称
纤连蛋白，牛血浆, solution, Extracellular matrix (ECM) glycoprotein, Suitable for cell adhesion, growth, migration, and differentiation.
description
Merck USA index - 14, 4075
form
solution
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
avoid repeated freeze/thaw cycles
shipped in
dry ice
storage temp.
−20°C
Quality Level
Analysis Note
通过SDS-PAGE获得单一条带
Application
牛血浆纤连蛋白已用作细胞外基质（ECM）底物以涂覆器皿或聚丙烯酰胺水凝胶，进而粘附：
- 人类黑色素瘤癌细胞
- 人乳腺上皮细胞
- 小鼠胚胎成纤维细胞
Biochem/physiol Actions
纤连蛋白在细胞粘附、生长、迁移和分化中发挥作用。它与一些分子结合，如整合素、肝素、纤维蛋白和胶原蛋白。
Disclaimer
毒性：标准处理（A）
General description
纤连蛋白是一种细胞外基质（ECM）糖蛋白。它在各种细胞类型中表达。纤连蛋白以二聚体形式存在，由相同的亚基组成，它们在C端通过二硫键共价连接。
Packaging
请参考特定浓度批号的标签。
Physical form
在150 mM NaCl，20 mM磷酸钠缓冲液（pH 7.3）中。
Preparation Note
初次融化后，等分并冷冻（-20°C）。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Purva Singh et al.
Annual review of cell and developmental biology, 26, 397-419 (2010-08-10)
In the process of matrix assembly, multivalent extracellular matrix (ECM) proteins are induced to self-associate and to interact with other ECM proteins to form fibrillar networks. Matrix assembly is usually initiated by ECM glycoproteins binding to cell surface receptors, such
Guillaume Jacquemet et al.
The Journal of cell biology, 216(10), 3387-3403 (2017-08-03)
Defective filopodia formation is linked to pathologies such as cancer, wherein actively protruding filopodia, at the invasive front, accompany cancer cell dissemination. Despite wide biological significance, delineating filopodia function in complex systems remains challenging and is particularly hindered by lack
Jordi Pijuan et al.
Frontiers in cell and developmental biology, 7, 107-107 (2019-07-02)
Cell migration is a key procedure involved in many biological processes including embryological development, tissue formation, immune defense or inflammation, and cancer progression. How physical, chemical, and molecular aspects can affect cell motility is a challenge to understand migratory cells
Fibronectin at a glance.
Roumen Pankov et al.
Journal of cell science, 115(Pt 20), 3861-3863 (2002-09-24)
Patrizia M Spoerri et al.
Nature materials, 19(2), 218-226 (2020-01-22)
Haematopoietic cells and platelets employ G-protein-coupled receptors (GPCRs) to sense extracellular information and respond by initiating integrin-mediated adhesion. So far, such processes have not been demonstrated in non-haematopoietic cells. Here, we report that the activation of protease-activated receptors PAR1 and
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