341635
Human Fibronectin
from human plasma, liquid, suitable for cell culture
别名:
人血浆纤连蛋白, 从人血浆中纯化的纤连蛋白，人纤连蛋白
产品名称
人血浆纤连蛋白, solution, suitable for cell culture
description
Merck USA index - 14, 4075
form
solution
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
avoid repeated freeze/thaw cycles
technique(s)
cell culture | mammalian: suitable
shipped in
wet ice
storage temp.
−20°C
Quality Level
Analysis Note
污染物：采用纤连蛋白抗血清或正常人血清，通过IEP未检出
通过SDS-PAGE获得单一主条带
Application
人血浆纤连蛋白已用于涂覆表面，如多聚-l-赖氨酸（PLL）包被的纳米芯片、聚丙烯酰胺（PAAm） 水凝胶基质、玻璃载玻片 等，为各种实验环境中细胞的粘附和培养提供基质。
Biochem/physiol Actions
人纤连蛋白在各种细胞行为（如细胞附着、迁移、胚胎发生、伤口愈合、组织完整性和恶变过程）中起关键作用。促使纤连蛋白支持细胞附着的关键特性之一是精氨酸-甘氨酸-天冬氨酸（RGD）三肽的存在。研究人员广泛研究了纤连蛋白在聚苯乙烯（PS）和聚乳酸羟基乙酸共聚物（PLGA）表面上的涂覆。此外，纤连蛋白是重要研究的对象，这些研究涉及其在调节过程中的参与情况，如分化至生长转换、微管蛋白单体生长、细胞周期状态、细胞扩散和运动。
Disclaimer
仅供研究使用。在法国，在用于科研目的时（包括进口和出口活动（《公共健康法》第L 1211-1条，第2节））该产品为管制品。购买者（即最终用户）需要获得《公共健康法》法第L 1211-1条规定的法国研究部的进口授权。订购本产品即表明您确认已经获得合适的进口授权。
毒性：标准处理（A）
General description
纤连蛋白是一种糖蛋白，属于细胞外基质（ECM）蛋白家族。纤连蛋白包含以羧基末端附近两个二硫键连接的两种多肽（α 和β链），形成二聚体。由人血浆中纯化的原生纤连蛋白 促进细胞附着于常用培养基质的有效试剂。
Other Notes
Akiyama, S.K., and Yamada, K.M.1987.Adv.Enzymol.59, 1.
Krejci, K., and Fritz, H. 1976.FEBS Lett.64, 152.
Selected Citations
Hoffmeister, M., et al. 2008.J. Biol. Chem.283, 2297.
Brown, S., et al. 2002.Nature418, 200.
Kim, M., FEBS Letters581 1917.
Krejci, K., and Fritz, H. 1976.FEBS Lett.64, 152.
Selected Citations
Hoffmeister, M., et al. 2008.J. Biol. Chem.283, 2297.
Brown, S., et al. 2002.Nature418, 200.
Kim, M., FEBS Letters581 1917.
Packaging
请参考特定浓度批号的标签。
Physical form
在PBS（pH 7.3）中。
Preparation Note
使用上述指南小心解冻。初次融化后，等分并冷冻（-20°C）。
由经认证测试对HBsAg以及HIV和HCV抗体阴性的血浆制备而成。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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Pietrocola G, et al.
Journal of Separation Science, 1627, 309-324 (2017)
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