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342000

Caspase Inhibitor, Negative Control

Name: Caspase Inhibitor, Negative Control
Brand: MM

The Caspase Inhibitor, Negative Control, also referenced under CAS 105637-38-5, controls the biological activity of Caspase. This small molecule/inhibitor is primarily used for Cancer applications.

别名:

Caspase Inhibitor, Negative Control, Z-FA-FMK, Cathepsin B, Inhibitor I

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About This Item

经验公式（希尔记法）:

C₂₁H₂₃FN₂O₄

CAS Number:

105637-38-5

分子量:

386.42

UNSPSC代码:

12352200

质量水平

100

方案

≥98% (HPLC)

表单

solid

制造商/商品名称

Calbiochem^®

储存条件

OK to freeze
desiccated

颜色

off-white

溶解性

DMSO: 10 mg/mL

运输

ambient

储存温度

−20°C

InChI

1S/C21H23FN2O4/c1-15(19(25)13-22)23-20(26)18(12-16-8-4-2-5-9-16)24-21(27)28-14-17-10-6-3-7-11-17/h2-11,15,18H,12-14H2,1H3,(H,23,26)(H,24,27)

InChI key

ASXVEBPEZMSPHB-UHFFFAOYSA-N

一般描述

A cell-permeable, irreversible cathepsin B inhibitor. Blocks LPS-induced production of IL-1α and IL-1β. Suitable as a negative control for caspase-1 and caspase-2 inhibitors because it lacks an aspartic acid residue at the P1 position.

生化/生理作用

Cell permeable: yes

Primary Target
Cathepsin-B

Product does not compete with ATP.

Reversible: no

警告

Toxicity: Standard Handling (A)

序列

Z-Phe-Ala-FMK

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Schotte, P., et al. 2001. J. Biol. Chem.276, 21153.
Guo, H., et al. 1998. Exp. Cell Res.245, 57.
Rosenthal, P.J., et al. 1993. J. Clin. Invest.91, 1057.
Ahmed, N.K., et al. 1992. Biochem. Pharmacol.44, 1201.
Rauber, P., et al. 1986. Biochem. J. 239, 633.
Shaw, E., et al. 1986. Biomed. Biochim. Acta 45, 1397.
Rasnick, D. 1985. Anal. Biochem. 149, 461.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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