343922
5-氟尿嘧啶
≥98% (HPLC), solid, thymidylate synthase inhibitor, Calbiochem®
别名:
5-氟尿嘧啶
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关于此项目
经验公式（希尔记法）:
C4H3FN2O2
化学文摘社编号:
分子量:
130.08
UNSPSC Code:
12171500
NACRES:
NA.77
MDL number:
产品名称
5-氟尿嘧啶, Potent antitumor agent.
SMILES string
Fc1[c]([nH][c]([nH]c1)=O)=O
InChI
1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)
InChI key
GHASVSINZRGABV-UHFFFAOYSA-N
description
Merck USA index - 14, 4181
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
hot water: 1 mg/mL
methanol: 1 mg/mL
DMF: 5 mg/mL
DMSO: 5 mg/mL
shipped in
ambient
storage temp.
2-8°C
Quality Level
Preparation Note
复溶后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多3个月。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
General description
强效抗肿瘤药。抑制氨基异丁酸-丙酮酸氨基转移酶。诱导人结肠癌细胞系的凋亡。
一种抑制氨基异丁酸-丙酮酸氨基转移酶的强效抗肿瘤药。诱导人结肠癌细胞系的凋亡。
Other Notes
Pressacco, J., et al. 1996.Br. J. Cancer72, 939.
Shchepotin, I.B., et al. 1994.Anticancer Res.14, 1027.
Shchepotin, I.B., et al. 1994.Anticancer Res.14, 1027.
Biochem/physiol Actions
主要靶标
氨基异丁酸-丙酮酸氨基转移酶
氨基异丁酸-丙酮酸氨基转移酶
产物不与ATP竞争。
可逆：否
细胞渗透性：否
Disclaimer
毒性：有害（C）
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Carc. 2
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
Chunfeng Liu et al.
Cell death and differentiation, 30(7), 1771-1785 (2023-05-21)
Curcumin, a natural phytochemical isolated from tumeric roots, represents a candidate for prevention and therapy of colorectal cancer/CRC. However, the exact mechanism of action and the downstream mediators of curcumin's tumor suppressive effects have remained largely unknown. Here we used
Adam Germain et al.
Oncology, 102(6), 515-524 (2023-11-27)
Cancers in general, and specifically lung cancer, continue to have low patient survival rates when the patient is at an advanced stage when diagnosed. It appears that the local environment, especially fibroblasts and their signaling molecules, tends to induce metastasis
商品
Discover critical characteristics to consider when working with enzyme inhibitors, such as cell permeability, the prozone effect, and Lipinski’s rule of 5.
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