A cell-permeable diaminopyrimidine compound that acts as a potent, selective, and ATP-competitive inhibitor of cFMS kinase activity (IC₅₀ = 30 nM) with minimal inhibition towards a panel of 26 other kinases (IC₅₀ >5 µM). Shown to selectively inhibit cFMS-mediated cellular functions in vitro as well as CSF-1-dependent tumor growth in vivo. A 10 mM (1 mg/273 µl) solution of cFMS Receptor Tyrosine Kinase Inhibitor (Cat. No. 344041) in DMSO is also available.

Primary Target
CFMS

Target IC₅₀: 30 nM against cFMS kinase activity

Toxicity: Standard Handling (A)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Conway, J.G., et al. 2005. Proc. Natl. Acad. Sci. USA102, 16078.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany