344101
FSB
A fluorine analog of the amyloidophilic fluorescent probe BSB that crosses the blood-brain barrier and displays low toxicity.
别名:
FSB, (E,E)-1-Fluoro-2,5- bis(3-hydroxycarbonyl-4-hydroxy)styrylbenzene
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关于此项目
经验公式（希尔记法）:
C24H17FO6
化学文摘社编号:
分子量:
420.39
MDL number:
UNSPSC Code:
41105331
NACRES:
NA.25
Assay:
≥95% (HPLC)
Form:
solid
Quality Segment
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
technique(s)
protein detection: suitable
color
yellow
solubility
DMSO: 200 mg/mL
shipped in
ambient
storage temp.
−20°C
SMILES string
Fc1c(ccc(c1)\C=C\c3cc(c(cc3)O)C(=O)O)\C=C\c2cc(c(cc2)O)C(=O)O
InChI key
DZXZHGCGNRRJEG-WMWQKROPSA-N
General description
A fluorine analog of the amyloidophilic fluorescent probe BSB (Cat. No. 286895) that crosses the blood-brain barrier and displays low toxicity (LD50 >80 mg/kg). Suitable for non-invasive amyloid visualization in living transgenic Tg2576 mice by using 19F and 1H-MRI (Magnetic Resonance Imaging). Also useful for staining plaques and neurofibrillary tangles in brain tissue sections of Alzheimer′s diseased patients with improved sensitivity, and reduced background.
This fluorine analog of the amyloidophilic fluorescent probe BSB (Cat. No. 286895) crosses the blood-brain barrier and displays low toxicity (LD50 >80 mg/kg). Suitable for non-invasive amyloid visualization in living transgenic Tg2576 mice by using 19F and 1H-MRI. Also useful for staining plaques and neurofibrillary tangles in brain tissue sections of Alzheimer′s diseased patients, with improved sensitivity and reduced background.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Amyloidophilic fluorescent probe
Amyloidophilic fluorescent probe
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Higuchi, M., et al. 2005. Nat. Neurosci.8, 527.
Sato, K., et al. 2004. Eur. J. Med. Chem.39, 573.
Sato, K., et al. 2004. Eur. J. Med. Chem.39, 573.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
怎么回事？
WGK 1
闪点 (F)
Not applicable
闪点 (°C)
Not applicable