344300
sFRP-1 Inhibitor
The sFRP-1 Inhibitor, also referenced under CAS 915754-88-0, controls the biological activity of sFRP-1. This small molecule/inhibitor is primarily used for Activators/Inducers applications.
别名:
sFRP-1 Inhibitor, Wnt Pathway Activator IV, N-(3-(Dimethylamino)propyl)-2-ethyl-5-(phenylsulfonyl)benzenesulfonamide, Secreted Frizzled Related Protein-1 Inhibitor
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关于此项目
经验公式（希尔记法）:
C19H26N2O4S2
化学文摘社编号:
分子量:
410.55
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
SMILES string
[S](=O)(=O)(NCCCN(C)C)c1c(ccc(c1)[S](=O)(=O)c2ccccc2)CC
InChI
1S/C19H26N2O4S2/c1-4-16-11-12-18(26(22,23)17-9-6-5-7-10-17)15-19(16)27(24,25)20-13-8-14-21(2)3/h5-7,9-12,15,20H,4,8,13-14H2,1-3H3
InChI key
BHFFSIFXFHJJNJ-UHFFFAOYSA-N
assay
≥95% (HPLC)
form
oil
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
clear
solubility
DMSO: 5 mg/mL
shipped in
ambient
Quality Level
General description
A diphenylsulfone-sulfonamide compound that counteracts the antagonizing effect of SARP-2/sFRP-1 (secreted frizzled related protein-1) against Wnt-3/frizzled interaction and Wnt-3/frizzled-stimulated cellular functions (EC50 = 1.27 µM in a U2OS-based reporter assay) with a reported aqueous solubility of 26 µg/ml at pH 7.4 and in vitro half-lives of 12 and 26.7 min using rat and human microsomes, respectively.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Gopalsamy, A., et al. 2008. J. Med. Chem.51, 7670.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
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