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344911

Fura-2 LR/AM

Name: Fura-2 LR/AM
Brand: MM

Acetoxymethyl (AM) derivative of FURA-PE3 with spectral properties similar to the parent compound.

别名:

Fura-2 LR/AM, Fura-2 Leakage Resistant (AM)

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关于此项目

经验公式（希尔记法）:

C₅₅H₆₃N₅O₂₉

化学文摘社编号:

172890-84-5

分子量:

1258.10

UNSPSC Code:

12171500

NACRES:

NA.25

MDL number:

MFCD00285848

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属性

Quality Level

100

assay

≥95% (HPLC)

form

gum

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

light yellow

solubility

DMSO: 10 mg/mL

fluorescence

λ_ex 368 nm (low), λ_ex 374 nm (high), λ_em 518 nm (low), λ_em 524 nm (high)

shipped in

ambient

storage temp.

−20°C

SMILES string

N1(CCN(CC1)C(=O)CCc2cc(c(cc2)N(CC(=O)OCOC(=O)C)CC(=O)OCOC(=O)C)OCCOc3cc4c([o]c(c4)c5ncc([o]5)C(=O)OCOC(=O)C)cc3N(CC(=O)OCOC(=O)C)CC(=O)OCOC(=O)C)CC(=O)OCOC(=O)C

InChI

1S/C55H63N5O29/c1-33(61)76-27-82-49(68)22-57-11-13-58(14-12-57)48(67)10-8-39-7-9-41(59(23-50(69)83-28-77-34(2)62)24-51(70)84-29-78-35(3)63)44(17-39)74-15-16-75-45-18-40-19-46(54-56-21-47(89-54)55(73)87-32-81-38(6)66)88-43(40)20-42(45)60(25-52(71)85-30-79-36(4)64)26-53(72)86-31-80-37(5)65/h7,9,17-21H,8,10-16,22-32H2,1-6H3

InChI key

CGAZNAYDEAJZHQ-UHFFFAOYSA-N

说明

General description

Acetoxymethyl (AM) derivative of FURA-PE3 with spectral properties similar to the parent compound. Can be loaded into cells in a manner similar to FURA 2/AM. Hydrolysis by non-specific esterases traps the indicator in the cytosol. Compared to FURA-2, it is retained longer in the cell. Note: 1 set = 10 x 50 µg.

An acetoxymethyl (AM) derivative of FURA-PE3. with spectral properties similar to the parent compound. Can be loaded into cells in a manner similar to FURA 2/AM (Cat. No. 344905). Hydrolysis by non-specific esterases traps the indicator in the cytosol. Spectral properties in the presence of low calcium concentrations (ex. 364 nm, em. 508 nm) differ from those during high calcium conditions (ex. 335 nm, em. 495 nm). Note: 1 set = 10 x 50 µg.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Calcium Probes

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Other Notes

Abe, F., et al. 1995. Br. J. Pharmacol.116, 3000.
Vorndran, C., et al. 1995. Biophys. J.69, 2114.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c