345752
Ganglioside GD3, Disialo, Diammonium Salt, Bovine Buttermilk
Has been characterized as one of the most important tumor-specific antigens in individuals with malignant melanoma.
别名:
Ganglioside GD₃, Disialo, Diammonium Salt, Bovine Buttermilk, Neu5Acα2,8Neu5Acα2,3Galβ1,4Glcβ1,1 Ceramide, 2NH4
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关于此项目
经验公式（希尔记法）:
C70H123N3O30 · 2NH4
分子量:
1522.80
NACRES:
NA.77
UNSPSC Code:
12352211
Quality Level
assay
≥98% (TLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
water: 1 mg/mL, chloroform/methanol (2:1): soluble
shipped in
ambient
storage temp.
−20°C
General description
Has been characterized as one of the most important tumor-specific antigens in individuals with malignant melanoma. Reported to disrupt mitochondrial transmembrane potential and induce apoptosis in tumor cells by a caspase-independent mechanism. Antibodies to GD3 can induce partial remission of tumor growth in animals and in humans via enhancement of cytotoxic and proliferative responses of lymphocytes. M.W. 1577.0 (based on tricosanoyl - 23:0).
Other Notes
DeMaria, R., et al. 1997. Science 277, 1652.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Sumeyye Cavdarli et al.
Cells, 10(6) (2021-07-03)
The O-acetylated form of GD2, almost exclusively expressed in cancerous tissues, is considered to be a promising therapeutic target for neuroectoderm-derived tumors, especially for breast cancer. Our recent data have shown that 9-O-acetylated GD2 (9-OAcGD2) is the major O-acetylated ganglioside
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 345752-1MG | 04055977193909 |