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Merck
CN

345810

G 418 硫酸盐，经细胞培养测试，大包装

G418 also known as Geneticin is an aminoglycoside antibiotic related to Gentamicin. Used as a selective agent in transfection of eukaryotic cells. Has highest potency ≥730 µg/mg and purity ≥98%.

别名:

G 418 硫酸盐，经细胞培养测试，大包装, G418，G 418，NMD抑制剂I

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经验公式（希尔记法）:
C20H40N4O10 · 2H2SO4
化学文摘社编号:
108321-42-2
分子量:
692.71
UNSPSC Code:
12352200
MDL number:
MFCD00058314

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InChI

1S/C20H40N4O10.2H2O4S/c1-6(25)14-11(27)10(26)9(23)18(32-14)33-15-7(21)4-8(22)16(12(15)28)34-19-13(29)17(24-3)20(2,30)5-31-19;2*1-5(2,3)4/h6-19,24-30H,4-5,21-23H2,1-3H3;2*(H2,1,2,3,4)/t6?,7-,8+,9+,10+,11-,12-,13-,14+,15+,16-,17-,18+,19-,20+;;/m0../s1

InChI key

UHEPSJJJMTWUCP-NKCAIAFTSA-N

assay

≥98% (TLC)

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

impurities

≤1.0% Ammonia

color

white

solubility

water: 100 mg/mL, clear, colorless

cation traces

heavy metals: ≤100 ppm

shipped in

ambient

storage temp.

10-30°C

Quality Level

100

General description

也提供无菌过滤水溶液（货号 345812），在 100 mM HEPES 中的无菌过滤溶液（货号 508940）和无菌过滤溶液 PBS（货号509227）中的25 mM溶液。

Preparation Note

重悬后，通过 0.22 µm 或 0.45 µm 孔径的过滤器过滤，等分并冷冻（-20°C）（长期储存），或冷藏（4°C）（短期储存）。无菌储备溶液在 -20°C 下可稳定保存长达 1 年。

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

毒性：标准处理（A）

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H317,H334

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

存储类别

12 - Non Combustible Liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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Qin Zhou et al.
Biotechnology journal, 16(9), e2000623-e2000623 (2021-05-31)
Chinese hamster ovary (CHO) cells with a high viable cell density (VCD), resilience to culture stress, and the capacity to continuously express recombinant proteins are highly desirable. Phosphatase and tension homology deleted on chromosome ten (PTEN) functions as a key
Transgene control engineering in mammalian cells.
Beat P Kramer et al.
Methods in molecular biology (Clifton, N.J.), 308, 123-143 (2005-08-06)
Wilfried Weber et al.
Methods in molecular biology (Clifton, N.J.), 267, 451-466 (2004-07-23)
Inducible expression of desired transgenes in mammalian cells and animals is a current priority in basic and applied research, biopharmaceutical manufacturing, gene therapy, and tissue engineering, as well as in drug discovery. Among the most prominent human-compatible transgene control technologies
Jiacheng Lin et al.
PLoS pathogens, 18(1), e1010204-e1010204 (2022-01-15)
The hepatitis B virus (HBV) core protein (HBc) functions in multiple steps of the viral life cycle. Heteroaryldihydropyrimidine compounds (HAPs) such as Bay41-4109 are capsid protein allosteric modulators that accelerate HBc degradation and inhibit the virion secretion of HBV, specifically
Yao Fan et al.
Cell death & disease, 13(4), 404-404 (2022-04-27)
Hepatitis B virus infection remains a major health problem worldwide due to its high risk of liver failure and hepatocellular carcinoma. Covalently closed circular DNA (cccDNA), which is present as an individual minichromosome, serves as the template for transcription of
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