347420
β-Glucuronidase, Helix pomatia
Native β-glucuronidase from Helix pomatia. Useful for hydrolyzing urinary steroid conjugates prior to steriod assays. Note: 1 MU = 1,000,000 units.
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biological source
Helix pomatia
Quality Level
description
Merck USA index - 14, 4466
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
do not freeze
solubility
aqueous buffer: soluble
foreign activity
Aryl sulfatase ≤2%
shipped in
wet ice
storage temp.
2-8°C
General description
Native β-glucuronidase from Helix pomatia. Useful for hydrolyzing urinary steroid conjugates prior to steriod assays. Note: 1 MU = 1,000,000 units.
Native β-glucuronidase from Helix pomatia. Useful for hydrolyzing urinary steroid conjugates prior to steriod assays. Note: 1 MU = 1,000,000 units.
Biochem/physiol Actions
β-Glucuronidase, a member of the 2 glycosyl hydrolase family, is involved in the hydrolysis of β-glucuronic acid residues from the non-reducing termini of glycosaminoglycans (GAGs). β-Glucuronidase catalyzes the complete hydrolysis of urinary conjugates. β-Glucuronidase serves as a possible candidate enzyme for gene-mediated enzyme prodrug therapy for glucuronide prodrugs. β-glucuronidase-responsive albumin binding prodrugs might be an effective therapeutic practice for treating solid tumors.
Physical form
A 65% saturated ammonium sulfate suspension.
Preparation Note
Following reconstitution, store in refrigerator (4°C). Stock solutions are stable for up to 3 months at 4°C.
Other Notes
One unit is defined as the amount of enzyme that will liberate 1.0 µg phenolphthalein from phenolphthalein glucuronide per h at 37°C, pH 5.0.
Shibasaki, H., et al. 2001. Steroids66, 795.
Graef, V., et al. 1977. Clin. Chem.23, 532.
Graef, V., et al. 1977. Clin. Chem.23, 532.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
signalword
Danger
hcodes
Hazard Classifications
Resp. Sens. 1 - Skin Sens. 1
存储类别
12 - Non Combustible Liquids
wgk
WGK 2
法规信息
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此项目有
Isabelle Tranoy-Opalinski et al.
European journal of medicinal chemistry, 74, 302-313 (2014-02-01)
The design of novel antitumor agents allowing the destruction of malignant cells while sparing healthy tissues is one of the major challenges in medicinal chemistry. In this context, the use of non-toxic prodrugs programmed to be selectively activated by beta-glucuronidase
K-C Chen et al.
Cancer gene therapy, 14(2), 187-200 (2006-09-16)
Gene-mediated enzyme prodrug therapy (GDEPT) seeks to increase the therapeutic index of anti-neoplastic agents by promoting selective activation of relatively nontoxic drug derivatives at sites of specific enzyme expression. Glucuronide prodrugs are attractive for GDEPT due to their low toxicity
Prabha Dwivedi et al.
Chemosphere, 199, 256-262 (2018-02-16)
Human exposure to consumer and personal care products chemicals such as phenols, including parabens and other antimicrobial agents, can be assessed through biomonitoring by quantifying urinary concentrations of the parent chemical or its metabolites, often after hydrolysis of phase II
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 347420-1MU | 04055977193176 |