349254
NS-398
A cell-permeable selective inhibitor of COX-2 in vitro.
别名:
NS-398, N-(2-Cyclohexyloxy-4-nitrophenyl)methanesulfonamide
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About This Item
经验公式（希尔记法）:
C13H18N2O5S
CAS Number:
分子量:
314.36
MDL编号:
UNSPSC代码:
41121800
NACRES:
NA.77
质量水平
方案
≥98% (TLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
颜色
pale yellow
溶解性
DMSO: 20 mg/mL
运输
ambient
储存温度
10-30°C
SMILES字符串
[S](=O)(=O)(Nc1c(cc(cc1)[N+](=O)[O-])OC2CCCCC2)C
InChI
1S/C13H18N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h7-9,11,14H,2-6H2,1H3
InChI key
KTDZCOWXCWUPEO-UHFFFAOYSA-N
一般描述
A cell-permeable selective inhibitor of COX-2 in vitro. Inhibits sheep placental COX-2 (IC50 = 3.8 µM) while COX-1 activity is unaffected at concentrations up to 100 µM. Displays potent anti-inflammatory and analgesic activity in vivo in rat at concentrations from 0.3 to 5 mg/kg.
A cell-permeable, selective inhibitor of cyclooxygenase-2 (COX-2) in vitro. Inhibits sheep placenta COX-2 (IC50 = 3.8 µM) while COX-1 activity is completely unaffected at concentrations up to 100 µM. Displays potent anti-inflammatory and analgesic activity in vivo in rat at concentrations of 0.3 to 5 mg/kg. Does not produce any significant gastrointestinal lesions even at single oral doses of 1000 mg/kg. A useful tool to explore the role of COX-2 in physiologic and pathophysiologic processes.
生化/生理作用
Cell permeable: yes
Primary Target
COX-2
COX-2
Product does not compete with ATP.
Reversible: no
Target IC50: 3.8 µM against COX-2
制备说明
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
其他说明
Ouellet, M., and Percival, M.D. 1995. Biochem. J.306, 247.
Futaki, N., et al. 1994. Prostaglandins47, 55.
Arai, I., et al. 1993. Res. Comm. Chem. Pathol. Pharmacol.81, 259.
Futaki, N., et al. 1993. Gen. Pharmacol.24, 105.
Futaki, N., et al. 1993. J. Pharm.Pharmacol.45, 753.
Futaki, N., et al. 1994. Prostaglandins47, 55.
Arai, I., et al. 1993. Res. Comm. Chem. Pathol. Pharmacol.81, 259.
Futaki, N., et al. 1993. Gen. Pharmacol.24, 105.
Futaki, N., et al. 1993. J. Pharm.Pharmacol.45, 753.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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