351801
Glucose Transporter Inhibitor III, STF-31
The Glucose Transporter Inhibitor III, STF-31 controls the biological activity of Glucose Transporter.
别名:
Glucose Transporter Inhibitor III, STF-31, STF-31
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关于此项目
Assay:
≥99% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥99% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 50 mg/mL
shipped in
wet ice
storage temp.
2-8°C
SMILES string
[S](=O)(=O)(NCc2ccc(cc2)C(=O)Nc3cnccc3)c1ccc(cc1)C(C)(C)C
InChI key
NGQPRVWTFNBUHA-UHFFFAOYSA-N
General description
A cell-permeable sulfonamide that selectively inhibits the growth of VHL-deficient renal cell carcinomas (RCCs) dose-dependently (0-5 µM) by directly targeting glucose transporter 1 (GLUT1), which is up-regulated by HIF (hypoxia-inducible factor) transcription factor in VHL-deficient cells. It elicits decreased oxidative phosphorylation associated with aerobic glycolysis and leads to necrosis, which is consistent with the effect induced by GLUT1 RNA interference. It does not bind to other glucose transporters, and does not inhibit a broad range of 50 tested kinases.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Chan, D., et al. 2011. Sci. Transl. Med.3, 94ra70.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
闪点 (°C)
Not applicable
警示词
Warning
危险代码
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
怎么回事？
WGK 3
闪点 (F)
Not applicable