Merck
CN
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文件

361515

Sigma-Aldrich

Glycogen Phosphorylase Inhibitor

The Glycogen Phosphorylase Inhibitor, also referenced under CAS 648926-15-2, controls the biological activity of Glycogen Phosphorylase.

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别名:
Glycogen Phosphorylase Inhibitor, 1-(3-(3-(2-Chloro-4,5-difluorobenzoyl)ureido)-4-methoxyphenyl)-3-methylurea
经验公式（希尔记法）:
C17H15ClF2N4O4
CAS号:
648926-15-2
分子量:
412.78

质量水平

100

检测方案

≥98% (HPLC)

形式

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
protect from light

颜色

white

溶解性

DMSO: 25 mg/mL

运输

ambient

储存温度

2-8°C

InChI

1S/C17H15ClF2N4O4/c1-21-16(26)22-8-3-4-14(28-2)13(5-8)23-17(27)24-15(25)9-6-11(19)12(20)7-10(9)18/h3-7H,1-2H3,(H2,21,22,26)(H2,23,24,25,27)

InChI key

ROJNYKZWTOHRNU-UHFFFAOYSA-N

一般描述

A cell-permeable urea compound that acts as a potent and AMP-competitive inhibitor of glycogen phosphorylase (GP; IC50 = 53 nM). Shown to inhibit glucagon-induced glyocgenolysis both in hepatocytes (IC50 = 380 nM) in vitro and in rats (5 mg/kg, iv) in vivo.

生化/生理作用

Cell permeable: yes
Primary Target
Glycogen phosphorylase
Product does not compete with ATP.
Reversible: no
Target IC50: 53 nM against glycogen phosphorylase

包装

Packaged under inert gas

警告

Toxicity: Irritant (B)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Klabunde, T., et al. 2005. J. Med. Chem.48, 6178

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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