361550
BIO
≥97% (HPLC), solid, GSK-3GSK-3α/β inhibitor, Calbiochem
别名:
GSK-3抑制剂IX, BIO，（2ʹZ，3ʹE)）-6-溴靛玉红-3ʹ-肟
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关于此项目
经验公式（希尔记法）:
C16H10BrN3O2
化学文摘社编号:
分子量:
356.17
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
GSK-3抑制剂IX, BIO, CAS 667463-62-9, is a cell-permeable, highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3α/β (IC50 = 5 nM). Maintains self-renewal in human & mouse embryonic stem cells.
SMILES string
Brc1cc2c(cc1)\C(=C3\Nc4c(cccc4)C\3N=O)\C(=O)N2
InChI
1S/C16H10BrN3O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)15-14(20-22)10-3-1-2-4-11(10)18-15/h1-7,14,18H,(H,19,21)/b15-13-
InChI key
WFRDXNRAUPBBTO-SQFISAMPSA-N
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
purple
solubility
DMSO: 5 mg/mL
shipped in
wet ice
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
产物与ATP竞争。
可逆性：是
细胞可渗透性：是
Disclaimer
毒性：致癌/致畸（D）
Packaging
用惰性气体包装
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Application
BIO has been used as a GSK-3 inhibitor:
- in aortic valve interstitial cells (VICs) culture to induce osteogenesis in VICs
- to treat VICs to study its effects on RUNX2, GSK-3β, and p-SMAD protein expression
- and a Wnt pathway activator to study the effect of Wnt and bone morphogenetic protein (BMP) pathways on Saos-2 using differentiation markers Dlx5, Runx2 and Msx2
General description
The small molecule, 6-bromoindirubin-3′-oxime (BIO) serves as a specific inhibitor of glycogen synthase kinase-3 (GSK-3). It can sustain self-renewal and pluripotency in both human and mouse embryonic stem cells (ESCs). Treating ESCs with BIO increases β-catenin activity, suggesting that the activation of canonical Wnt signaling plays a key role in preserving the stem cell characteristics. BIO can also induce adult mammalian cardiomyocytes to dedifferentiate and enter mitosis. In addition to its effects on stem cells, the GSK-3 inhibitor IX (BIO) has the ability to elevate the expression of caspase-3 and caspase-8 proteins, leading to the induction of apoptosis in glioblastoma (GBM) cells. This GSK-3 inhibitor also triggers G2/M cell cycle arrest in GBM cells.
存储类别
11 - Combustible Solids
wgk
WGK 3
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