361555
GSK-3 Inhibitor XIII
The GSK-3 Inhibitor XIII, also referenced under CAS 404828-08-6, controls the biological activity of GSK-3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
GSK-3 Inhibitor XIII, (5-Methyl-1H-pyrazol-3-yl)-(2-phenylquinazolin-4-yl)amine
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关于此项目
经验公式（希尔记法）:
C18H15N5
化学文摘社编号:
分子量:
301.35
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
SMILES string
[nH]1nc(cc1Nc2nc(nc4c2cccc4)c3ccccc3)C
InChI
1S/C18H15N5/c1-12-11-16(23-22-12)20-18-14-9-5-6-10-15(14)19-17(21-18)13-7-3-2-4-8-13/h2-11H,1H3,(H2,19,20,21,22,23)
InChI key
JYCUVOXSZBECAY-UHFFFAOYSA-N
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 5 mg/mL
shipped in
ambient
Quality Level
General description
A potent and ATP-competitive inhibitor of GSK-3 (Ki = 24 nM).
An aminopyrazole compound that acts as a potent and ATP-binding site inhibitor of GSK-3 with a Ki of 24 nM.
Biochem/physiol Actions
Cell permeable: no
Primary Target
GSK-3
GSK-3
Product does not compete with ATP.
Reversible: no
Target Ki: 24 nM against GSK-3
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Pierce, A.C., et al. 2005. J. Med. Chem.48, 1278.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Carcinogenic / Teratogenic (D)
存储类别
11 - Combustible Solids
wgk
WGK 1
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