365250
Gö 6976
≥95% (HPLC), protein kinase C inhibitor, solid
别名:
Gö 6976
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选择规格
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关于此项目
经验公式（希尔记法）:
C24H18N4O
化学文摘社编号:
分子量:
378.43
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥95% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
产品名称
Gö 6976, Gö 6976, CAS 136194-77-9, is a cell-permeable, reversible, and ATP-competitive inhibitor of PKC (IC50 = 7.9 nM for rat brain). Exhibits selectively for PKCα (IC50 = 2.3 nM) and βI (IC50 = 6.2 nM).
Quality Segment
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
DMSO: 5 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
[n]1(c2c3[n](c4c(c3c5c(c2c6c1cccc6)CNC5=O)cccc4)C)CCC#N
InChI
1S/C24H18N4O/c1-27-17-9-4-2-7-14(17)20-21-16(13-26-24(21)29)19-15-8-3-5-10-18(15)28(12-6-11-25)23(19)22(20)27/h2-5,7-10H,6,12-13H2,1H3,(H,26,29)
InChI key
VWVYILCFSYNJHF-UHFFFAOYSA-N
General description
一种细胞可渗透性、可逆和ATP竞争性的蛋白激酶C（PKC；大鼠脑的IC50=7.9 nM）抑制剂。选择性抑制Ca2+依赖性PKCα-同工酶（IC50=2.3 nM）和PKCβI（IC50=6.2 nM）。即使在微摩尔水平下，也不会影响不依赖Ca2+的PKCδ-，ε-和ζ-同工酶的激酶活性。据报道，在较高浓度（IC50=20 nM）下可抑制PKCµ。也可获得500 µg/mL的Gö 6976（目录编号365253）在无水DMSO中的溶液。
Biochem/physiol Actions
主要靶标
PKC
PKC
产物与ATP竞争。
可逆性：是
细胞可渗透性：是
靶标IC50：7.9 nM，针对大鼠脑PKC；针对Ca2+依赖性PKCα-同工酶和PKCβI分别为2.3 nM和6.2 nM
Preparation Note
复溶后，等分并冷冻保存（-20°C）。储备液可在-20°C最长稳定4个月。
Other Notes
Gschwendt, M., et al. 1996.FEBS Lett.392, 77.
Wenzel-Seifert, K., et al. 1994.Biochem.Biophys.Res. Commun.200, 1536.
Martiny-Baron, G.M., et al. 1993.J. Biol. Chem.268, 9194.
Qatsha, K.A., et al. 1993.Proc.Natl.Acad.Sci. USA90, 4674.
Wenzel-Seifert, K., et al. 1994.Biochem.Biophys.Res. Commun.200, 1536.
Martiny-Baron, G.M., et al. 1993.J. Biol. Chem.268, 9194.
Qatsha, K.A., et al. 1993.Proc.Natl.Acad.Sci. USA90, 4674.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable